1.

Record Nr.

UNINA9910437832303321

Titolo

Host-Pathogen Interactions in Streptococcal Diseases [[electronic resource] /] / edited by G Singh Chhatwal

Pubbl/distr/stampa

Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013

ISBN

3-642-43836-9

3-642-36340-7

Edizione

[1st ed. 2013.]

Descrizione fisica

1 online resource (258 p.)

Collana

Current Topics in Microbiology and Immunology, , 0070-217X ; ; 368

Disciplina

579.3

610

611.01816

613

614

615.372

616.079

616.9/298

616.9041

Soggetti

Medical microbiology

Immunology

Vaccines

Molecular biology

Public health

Bacteriology

Medical Microbiology

Vaccine

Molecular Medicine

Public Health

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

Group A Streptococcal Diseases and Their Global Burden -- Molecular Markers for the Study of Streptococcal Epidemiology -- Epidemiology



and Pathogenicity of Zoonotic Streptococci -- Adherence and Invasion of Streptococci to Eukaryotic Cells and Their Role in Disease Pathogenesis -- Common Regulators of Virulence in Streptococci -- Host-Pathogen Interactions in Streptococcal Immune Sequelae -- Immunopathogenesis of Streptococcal Deep Tissue Infections -- Modulation of the Coagulation System During Severe Streptococcal Disease -- Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine -- Clinical Management of the Most Common Group A β-Hemolytic Streptococcal Infections.

Sommario/riassunto

Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.