Genomics of Pattern Recognition Receptors : Applications in Oncology and Cardiovascular Diseases / / by Anton G. Kutikhin, Arseniy E. Yuzhalin

• Record Nr.: UNINA9910437623603321
• Autore: Kutikhin Anton G
• Pubbl/distr/stampa: Basel : , : Springer Basel : , : Imprint : Springer, , 2013
• ISBN: 3-0348-0688-4
• Edizione: [1st ed. 2013.]
• Descrizione fisica: 1 online resource (190 p.)
• Disciplina: 570; 572696; 574.87; 599935
• Soggetti: Proteins ; Immunology; Cancer research; Human genetics; Oncology ; Cardiology; Receptors; Cancer Research; Human Genetics; Oncology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and ; Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
• Sommario/riassunto: This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.