1.

Record Nr.

UNINA9910437621803321

Titolo

Genetic and Molecular Epidemiology of Multiple Myeloma [[electronic resource] /] / edited by Suzanne Lentzsch

Pubbl/distr/stampa

New York, NY : , : Springer New York : , : Imprint : Springer, , 2013

ISBN

1-4614-4660-0

1-299-19720-5

Edizione

[1st ed. 2013.]

Descrizione fisica

1 online resource (130 p.)

Disciplina

571.6

599935

610

611.01816

Soggetti

Cancer research

Cell biology

Human genetics

Cancer Research

Cell Biology

Human Genetics

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Preface -- Genetics of Multiple Myeloma -- Gene expression signature in MGUS and multiple myeloma -- Cap-Dependent Protein Translation Initiation in Multiple Myeloma: an Attractive Target for Therapy -- IRES-dependent, CAP-independent translation in Multiple Myeloma -- Epigenetic gene silencing as a new target for multiple myeloma -- Role of Bone Disease in the Pathogenesis of Multiple Myeloma -- Index.

Sommario/riassunto

This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.  Areas, which are covered include the characterization of different myeloma entities by genomics



and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.