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Record Nr. |
UNINA9910437607903321 |
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Titolo |
DNA repair of cancer stem cells / / Lesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, editors |
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Pubbl/distr/stampa |
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Dordrecht, : Springer, 2012, c2013 |
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ISBN |
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1-283-52913-0 |
9786613841582 |
94-007-4590-7 |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (179 p.) |
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Altri autori (Persone) |
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MathewsLesley A |
CabarcasStephanie M |
HurtElaine M |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Preface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index. |
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Sommario/riassunto |
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The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and |
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