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1. |
Record Nr. |
UNINA9910419855903321 |
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Autore |
Mela, Alfredo <1948- > |
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Titolo |
La città postmoderna : spazi e culture / Alfredo Mela |
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Pubbl/distr/stampa |
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Roma, : Carocci editore, 2020 |
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Collocazione |
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307.76 MEL 6 |
URB.LE B 3305 |
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Livello bibliografico |
Monografia |
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2. |
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UNINA9910598495703321 |
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Autore |
Vogt, Joseph |
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Titolo |
Constantin der Grosse und Seinjahrundert / Vogt, Joseph |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910298411803321 |
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Titolo |
Autophagy in Health and Disease : Potential Therapeutic Approaches / / edited by Kursad Turksen |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Humana, , 2018 |
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Edizione |
[1st ed. 2018.] |
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Descrizione fisica |
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1 online resource (182 pages) |
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Collana |
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Stem Cell Biology and Regenerative Medicine, , 2196-8985 |
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Disciplina |
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Cell cycle |
Cell physiology |
Pharmaceutical technology |
Metabolic diseases |
Cell Cycle Analysis |
Cell Physiology |
Pharmaceutical Sciences/Technology |
Metabolic Diseases |
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Nota di contenuto |
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Autophagy and Stem cells -- Fine-Tuning the Stem Cell Fate by Autophagy -- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine -- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis -- The Role of mTOR in Osteoclasts -- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration -- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration -- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response -- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases -- Virus and Autophagy: Enemies or Allies -- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives. |
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This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students. |
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4. |
Record Nr. |
UNINA9910346841703321 |
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Autore |
Tosello Guido |
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Titolo |
Product/Process Fingerprint in Micro Manufacturing / Guido Tosello |
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Pubbl/distr/stampa |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (274 p.) |
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The continuous miniaturization of products and the growing complexity of their embedded multifunctionalities necessitates continuous research and development efforts regarding micro components and related micro manufacturing technologies. Highly miniaturized systems, manufactured using a wide variety of materials, have found application in key technological fields, such as healthcare devices, micro implants, mobility, communications, optics, and micro electromechanical systems. Innovations required for the high-precision manufacturing of micro components can specifically be achieved through optimizations using post-process (i.e., offline) and in-process (i.e., online) metrology of both process input and output parameters, as well as geometrical features of the produced micro parts. However, it is of critical importance to reduce the metrology and optimization efforts, since process and product quality control can represent a significant portion of the total production time in micro manufacturing. To solve this fundamental challenge, research efforts have been undertaken in order to define, investigate, implement, and validate the so-called "product/process manufacturing fingerprint" concept. The "product manufacturing fingerprint" concept refers to those unique dimensional outcomes (e.g., surface topography, form error, critical dimensions, etc.) on the produced component that, if kept under control and within specifications, ensure that the entire micro component complies to its |
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specifications. The "process manufacturing fingerprint" is a specific process parameter or feature to be monitored and controlled, in order to maintain the manufacture of products within the specified tolerances. By integrating both product and process manufacturing fingerprint concepts, the metrology and optimization efforts are highly reduced. Therefore, the quality of the micro products increases, with an obvious improvement in production yield. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments and applications in micro- and sub-micro-scale manufacturing, process monitoring and control, as well as micro and sub-micro product quality assurance. Focus will be on micro manufacturing process chains and their micro product/process fingerprint, towards full process optimization and zero-defect micro manufacturing. |
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