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1. |
Record Nr. |
UNINA9910418327703321 |
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Titolo |
Advances in Offshore Geotechnics [[electronic resource] ] : Proceedings of ISOG2019 / / edited by Sumanta Haldar, Shantanu Patra, Ravindra K. Ghanekar |
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Pubbl/distr/stampa |
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (XVI, 429 p. 330 illus., 253 illus. in color.) |
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Collana |
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Lecture Notes in Civil Engineering, , 2366-2557 ; ; 92 |
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Disciplina |
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Soggetti |
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Ocean engineering |
Engineering geology |
Engineering—Geology |
Foundations |
Hydraulics |
Geotechnical engineering |
Offshore Engineering |
Geoengineering, Foundations, Hydraulics |
Geotechnical Engineering & Applied Earth Sciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Design of anchoring systems for deep water soft sediments -- Use of onshore test sites for offshore geotechnical problems -- Optimising geotechnical engineering models (GEMs) -- Challenge in geotechnical engineering on Methane Hydrate production -- Lattice leg-soil interaction effects in deeply embedded spudcan foundations -- Developing screw piles for offshore renewable energy application -- Challenges in the design and construction of offshore wind turbine foundations including sites in seismic areas -- Evaluation of offshore pile capacity and pile integrity using dynamic pile monitoring services -- Geotechnical Characterisation of Krishna Godavari Basin Sediments, Offshore Eastern India -- Back analyses of jack-up rig penetration for punch through case. . |
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Sommario/riassunto |
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This book comprises select proceedings of the First Indian Symposium |
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on Offshore Geotechnics. It addresses state of the art and emerging challenges in offshore design and construction. The theme papers from leading academicians and practitioners provide a comprehensive overview of the broad topics encompassing various challenges in offshore geotechnical engineering. It covers various aspects pertaining to offshore geotechnics, such as offshore site investigation, soil characterization, geotechnics related to offshore renewable energy converters, offshore foundations and anchoring systems, pipelines, and deep sea explorations. This volume provides a comprehensive reference for professionals and researchers in offshore, civil and maritime engineering and for soil mechanics specialists. |
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2. |
Record Nr. |
UNICASUBO0095079 |
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Autore |
Tuan, Laura |
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Titolo |
Il grande dizionario dei sogni / Laura Tuan |
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Pubbl/distr/stampa |
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Milano, : De Vecchi, c1988 |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNIORUON00052554 |
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Autore |
PIKULIN, Mixail Grigor'evic |
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Titolo |
Beludzi / M. G. Pikulin |
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Pubbl/distr/stampa |
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Moskva, : Izd. Vostocnoj Literatury, 1959 |
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Descrizione fisica |
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Classificazione |
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Soggetti |
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PAKISTAN - CULTURA E CIVILTA' |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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4. |
Record Nr. |
UNINA9910220059703321 |
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Autore |
Kristin Zorn |
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Titolo |
Inhibiting PARP as a Strategic Target in Cancer |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (97 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and |
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other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage. |
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