Sialo-Xenoantigenic Glycobiology : Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation / / by Kwon-Ho Song, Cheorl-Ho Kim

• Record Nr.: UNINA9910437894503321
• Pubbl/distr/stampa: Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013
• ISBN: 1-283-91007-1; 3-642-34094-6
• Edizione: [1st ed. 2013.]
• Descrizione fisica: 1 online resource (75 p.)
• Collana: Sungkyunkwan University Outstanding Research, , 2195-3554 ; ; 1
• Altri autori (Persone): SongKwon-ho; KimCheorl-ho
• Disciplina: 572.567
• Soggetti: Biomedical engineering; Medicine - Research; Biology - Research; Medical genetics; Clinical biochemistry; Biochemistry; Biomedical Engineering and Bioengineering; Biomedical Research; Medical Genetics; Medical Biochemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Screening of pig glycosyltransferase genes related to xenoantigens and their masking -- Cloning and tissue specific expression of pcmah and its alternative transcripts -- Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation -- Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene -- Screening for xenoantigenic determinants formed by sialyltransferases.
• Sommario/riassunto: Carbohydrate antigens on glycoconjugates of mammalian cells play ; crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented. .

Highlights in Practical Applications of Agents, Multi-Agent Systems, and Trust-worthiness. The PAAMS Collection : International Workshops of PAAMS 2020, L'Aquila, Italy, October 7–9, 2020, Proceedings / / edited by Fernando De La Prieta, Philippe Mathieu, Jaime Andrés Rincón Arango, Alia El Bolock, Elena Del Val, Jaume Jordán Prunera, João Carneiro, Rubén Fuentes, Fernando Lopes, Vicente Julian

• Record Nr.: UNINA9910413443103321
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
• ISBN: 3-030-51999-6
• Edizione: [1st ed. 2020.]
• Descrizione fisica: 1 online resource (XIV, 418 p. 137 illus., 93 illus. in color.)
• Collana: Communications in Computer and Information Science, , 1865-0937 ; ; 1233
• Disciplina: 006.3
• Soggetti: Artificial intelligence; Application software; Computer networks; Computers, Special purpose; Electronic commerce; Artificial Intelligence; Computer and Information Systems Applications; Computer Communication Networks; Special Purpose and Application-Based Systems; e-Commerce and e-Business
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Includes index.
• Nota di contenuto: Workshop on Agent-Based Artificial Markets Computational Economics (ABAM) -- Workshop on Agents and Edge-AI (AgEdAI) -- Workshop on Character Computing (C2) -- Workshop on MAS for Complex Networks and Social Computation (CNSC) -- Workshop on Decision Support, Recommendation, and Persuasion in Artificial Intelligence (DeRePAI) -- Workshop on Multi-Agent Systems and Simulation (MAS&S) -- Workshop on Multi-agent based Applications for Energy Markets, Smart Grids and Sustainable Energy Systems (MASGES) -- Workshop on Smart ; Cities and Intelligent Agents (SCIA).
• Sommario/riassunto: This book constitutes the refereed proceedings of the workshops co-located with the 18th International Conference on Practical Applications of Agents and Multi-Agent Systems, PAAMS 2020, held in L’Aquila, Italy, in October 2020. The total of 21 full and 13 short papers presented in this volume were carefully reviewed and selected from 57 submissions. The papers in this volume stem from the following meetings: Workshop on Agent-Based Artificial Markets Computational Economics (ABAM); Workshop on Agents and Edge-AI (AgEdAI); Workshop on Character Computing (C2); Workshop on MAS for Complex Networks and Social Computation (CNSC); Workshop on Decision Support, Recommendation, and Persuasion in Artificial Intelligence (DeRePAI); Workshop on Multi-Agent Systems and Simulation (MAS&S); Workshop on Multi-agent based Applications for Energy Markets, Smart Grids and Sustainable Energy Systems (MASGES); Workshop on Smart Cities and Intelligent Agents (SCIA).