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Record Nr. |
UNINA9910410051803321 |
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Autore |
Bao Xiucong |
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Titolo |
Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation [[electronic resource] /] / by Xiucong Bao |
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Pubbl/distr/stampa |
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (XVIII, 163 p. 132 illus., 96 illus. in color.) |
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Collana |
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Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053 |
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Disciplina |
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Soggetti |
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Bioorganic chemistry |
Posttranslational modification |
Proteins |
Proteomics |
Gene expression |
Cell cycle |
Bioorganic Chemistry |
Posttranslational Modification |
Protein Structure |
Gene Expression |
Cell Cycle Analysis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Doctoral Thesis accepted by The University of Hong Kong, China"--Title page. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Introduction to Protein Posttranslational Modifications (PTMs) -- Chemical reporter for Lysine Malonylation -- Identification of Histone Lysine Glutarylation -- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly -- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach. |
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Sommario/riassunto |
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This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which |
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