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Record Nr. |
UNINA9910373917803321 |
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Titolo |
Actin Polymerization in Apicomplexan : A Structural, Functional and Evolutionary Analysis / / edited by Avinash Kale |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (XI, 101 p. 11 illus. in color.) |
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Disciplina |
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Soggetti |
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Parasitology |
Biomechanics |
Proteins |
Bioinformatics |
Protein Biochemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan. |
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Sommario/riassunto |
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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As |
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the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. |
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