Co-signal Molecules in T Cell Activation : Immune Regulation in Health and Disease / / edited by Miyuki Azuma, Hideo Yagita

• Record Nr.: UNINA9910373916903321
• Pubbl/distr/stampa: Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019
• ISBN: 981-329-717-4
• Edizione: [1st ed. 2019.]
• Descrizione fisica: 1 online resource (VI, 326 p. 22 illus., 21 illus. in color.)
• Collana: Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 1189
• Disciplina: 616.079
• Soggetti: Immunology; Cancer - Research; Neurology; Oncology; Cancer Research; Cèl·lules T; Immunologia; Llibres electrònics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Part I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. .
• Sommario/riassunto: This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-; stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. .