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1. |
Record Nr. |
UNINA9911009243603321 |
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Autore |
Kaldellis Anthony |
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Titolo |
The Case for East Roman Studies |
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Pubbl/distr/stampa |
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Amsterdam : , : Arc Humanities Press, , 2024 |
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©2024 |
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ISBN |
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9781802702552 |
1802702555 |
9781802702545 |
1802702547 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (112 pages) |
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Collana |
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Disciplina |
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Soggetti |
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HISTORY / Medieval |
Byzantine Empire Study and teaching |
Empire byzantin Étude et enseignement |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Frontmatter -- Contents -- Introduction -- Chapter 1 RIP Byzantium -- Chapter 2 Contenders for a New Field-Name -- Chapter 3 Implications for Allied Fields -- Conclusions -- Further Reading |
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Sommario/riassunto |
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Byzantine Studies has reached a tipping point: a growing number of historians have realized that the terms "Byzantium" and "the Byzantines" distort the reality and identity of the society that we study, and encode a series of prejudices that were embedded in western perceptions. The aim of these terms was to exclude the eastern empire from important discussions and historical developments.It is time to end this exercise in orientalist fiction, but what are the alternatives? In this book, Anthony Kaldellis surveys the pros and cons of a range of possible options and examines the implications of a field name-change also for art history, philology, and the study of Eastern Orthodoxy. The new name he proposes will carry the field into the next phase of its history, renegotiate its relationships with its peers and respect the testimony of our sources. |
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2. |
Record Nr. |
UNINA9910367759103321 |
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Autore |
Gazy Inbal |
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Titolo |
Towards Mechanism-based Treatments for Fragile X Syndrome / Inbal Gazy, Daman Kumari |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (250 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS. |
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