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1. |
Record Nr. |
UNINA9910367756603321 |
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Autore |
Wang Quanrong |
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Titolo |
Advances in Groundwater Flow and Solute Transport : : Pushing The Hidden Boundary / / Quanrong Wang, Zhang Wen, Hongbin Zhan |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (196 p.) |
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Soggetti |
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Environmental science, engineering & technology |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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In recent decades, the study of groundwater flow and solute transport has advanced into new territories that are beyond conventional theories, such as Darcy's law and Fick's law. The studied media have changed from permeable porous and fractured ones to much less permeable ones, such as clay and shale. The studied pore sizes have also changed from millimetres to micro-meters or even nano-meters. The objective of this Special Issue is to report recent advances in groundwater flow and solute transport that push the knowledge boundary into new territories which include, but are not limited to, flow and transport in sloping aquifer/hillslopes, coupled unsaturated and saturated flow, coupled aquifer-vertical/horizontal/slant well flow, interaction of aquifer with connected and disconnected rivers, non-Darcian flow, anomalous transport beyond the Fickian scheme, and flow and transport in extremely small pore spaces such as shale and tight sandstones. Contributions focusing on innovative experimental, numerical, and analytical methods for understanding unconventional problems, such as the above-listed ones, are encouraged, and contributions addressing flow and transport at interfaces of different media and crossing multiple temporal and spatial scales are of great value |
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2. |
Record Nr. |
UNINA9910367754703321 |
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Autore |
Kwok Hang Fai Henry |
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Titolo |
Venom and Toxin as Targeted Therapy / Hang Fai Henry Kwok |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (180 p.) |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous |
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evaluation and revision by expert peer reviewers. |
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