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Record Nr. |
UNINA9910367756303321 |
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Autore |
Haas Richard H |
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Titolo |
Mitochondrial Dysfunction in Aging and Diseases of Aging / Richard H. Haas |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (270 p.) |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process. |
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2. |
Record Nr. |
UNINA9910367565503321 |
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Autore |
López de Lacalle Luis Norberto |
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Titolo |
Machining-Recent Advances, Applications and Challenges / Luis Norberto López de Lacalle, Gorka Urbicain |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Basel, Switzerland : , : MDPI, , 2019 |
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ISBN |
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Descrizione fisica |
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1 electronic resource (554 p.) |
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History of engineering and technology |
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Monografia |
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The Special Issue Machining-Recent Advances, Applications and Challenges is intended as a humble collection of some of the hottest topics in machining. The manufacturing industry is a varying and challenging environment where new advances emerge from one day to another. In recent years, new manufacturing procedures have retained increasing attention from the industrial and scientific community. However, machining still remains the key operation to achieve high productivity and precision for high-added value parts. Continuous research is performed, and new ideas are constantly considered. This Special Issue summarizes selected high-quality papers which were submitted, peer-reviewed, and recommended by experts. It covers some (but not only) of the following topics: High performance operations for difficult-to-cut alloys, wrought and cast materials, light alloys, ceramics, etc.; Cutting tools, grades, substrates and coatings. Wear damage; Advanced cooling in machining: Minimum quantity of lubricant, dry or cryogenics; Modelling, focused on the reduction of risks, the process outcome, and to maintain surface integrity; Vibration problems in machines: Active and passive/predictive methods, sources, diagnosis and avoidance; Influence of machining in new concepts of machine-tool, and machine static and dynamic behaviors; Machinability |
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of new composites, brittle and emerging materials; Assisted machining processes by high-pressure, laser, US, and others; Introduction of new analytics and decision making into machining programming. We wish to thank the reviewers and staff from Materials for their comments, advice, suggestions and invaluable support during the development of this Special Issue. |
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