1.

Record Nr.

UNINA9910349504303321

Autore

de Jesus Jemmyson Romário

Titolo

Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals / / by Jemmyson Romário de Jesus

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019

ISBN

3-030-29473-0

Edizione

[1st ed. 2019.]

Descrizione fisica

1 online resource (108 pages)

Collana

Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053

Disciplina

610.28

Soggetti

Analytical chemistry

Psychobiology

Proteomics

Pharmaceutical chemistry

Analytical Chemistry

Biological Psychology

Medicinal Chemistry

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Doctoral thesis accepted by the University of Campinas, Campinas, Brazil"--Title page.

Nota di contenuto

Introduction -- Application of a Proteomic Strategy for the Identification of Differential Proteins Candidates to Biomarkers of Bipolar Disorder -- Application of the Ionomic Strategy to Evaluate Possible Differences in Metal Ion Concentration Between Patients with Bipolar Disorder and other Psychiatric Disorders -- Development of a New Polymer Membrane Based Methodology for Characterization of the Urine Proteome -- Final Conclusion. .

Sommario/riassunto

This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in



misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.