1.

Record Nr.

UNINA9910349440803321

Titolo

Ferroptosis in Health and Disease / / edited by Daolin Tang

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019

ISBN

3-030-26780-6

Edizione

[1st ed. 2019.]

Descrizione fisica

1 online resource (VI, 324 p. 36 illus., 35 illus. in color.)

Disciplina

571.6

Soggetti

Cell physiology

Apoptosis

Human physiology

Proteins 

Oxidative stress

Cell Physiology

Human Physiology

Protein Science

Oxidative Stress

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Lipid metabolism and ferroptosis -- 2. Iron metabolism and ferroptosis -- 3. Regulation and Function of Autophagy During Ferroptosis -- 4.Heat Shock Proteins: Endogenous Modulators of Ferroptosis -- 5. Biological Aspects of Endoplasmic Reticulum Stress in Ferroptosis -- 6. Gpx4 in ferroptosis -- 7. ACSL4 as the First Reliable Biomarker of Ferroptosis Under Pathophysiological Conditions -- 8. Regulation of Ferroptosis by MicroRNAs -- 9. Ferroptosis in Cardiovascular Disease -- 10. Ferroptosis in Nervous System Diseases -- 11. Regulation of Ferroptosis Through the Cysteine-Glutathione Redox Axis -- 12. Iron-Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease -- 13. Ferroptosis in Liver Disease -- 14. p53 and Ferroptosis -- 15. Ferroptosis in Hemolytic Disorders -- 16. Lipoxygenase in Ferroptosis -- 17. Ferroptosis in Cancer Disease -- 18. Ferroptosis in Cancer Therapy.



Sommario/riassunto

This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research. .