1.

Record Nr.

UNINA9910557489703321

Autore

Uchino Junji

Titolo

Non-small Cell Lung Cancer: Current Therapies and New Targeted Treatments

Pubbl/distr/stampa

Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021

Descrizione fisica

1 electronic resource (258 p.)

Soggetti

Medicine

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Sommario/riassunto

Conventional lung cancer treatments were once limited to surgery, radiation, and chemotherapy. However, gefitinib, a targeted drug, was launched in 2004, and the situation changed. Cancer cases that were highly responsive to gefitinib were later discovered to have epithelial growth factor receptor (EGFR) mutations. This discovery opened the door for biomarker-based treatment strategies. Subsequently, several EGFR-tyrosine kinase inhibitors (TKI) were developed, and they became a new mainstay of treatment for non-small cell lung cancer. In recent years, many mechanisms of resistance to EGFR-TKI have been elucidated; a mutation in the T790M gene at exon 20 is found in half of the resistant cases. Hence, osimertinib, which specifically inhibits EGFR despite this T790M gene mutation, was developed to achieve long-term progression-free survival. Other driver mutations that are similar to the EGFR mutation were discovered, including the EML4-ALK fusion gene (discovered in 2007), ROS1 gene, and BRAF gene mutations. The TKIs for each of these fusion genes were developed and are used as therapeutic agents. Another advancement in advanced non-small cell lung cancer is the development of immune checkpoint inhibitors. Four PD-1/PD-L1 inhibitors, including nivolumab, are currently available for treatment of lung cancer. These drugs prevent an escape from the cancer immunity cycle. This ensures that cancer cells will express cancer antigens, causing an anticancer immune response. Due to



cancer immunotherapy, long-term survival is possible. The biomarker development for cancer immunotherapy and its side effects are actively being studied.

2.

Record Nr.

UNINA9910349278103321

Titolo

Ad-Hoc, Mobile, and Wireless Networks : 18th International Conference on Ad-Hoc Networks and Wireless, ADHOC-NOW 2019, Luxembourg, Luxembourg, October 1–3, 2019, Proceedings / / edited by Maria Rita Palattella, Stefano Scanzio, Sinem Coleri Ergen

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019

ISBN

3-030-31831-1

Edizione

[1st ed. 2019.]

Descrizione fisica

1 online resource (XV, 645 p. 262 illus., 188 illus. in color.)

Collana

Computer Communication Networks and Telecommunications ; ; 11803

Disciplina

004.685

Soggetti

Computer communication systems

Special purpose computers

Computer system failures

Application software

Coding theory

Information theory

Data encryption (Computer science)

Computer Communication Networks

Special Purpose and Application-Based Systems

System Performance and Evaluation

Information Systems Applications (incl. Internet)

Coding and Information Theory

Cryptology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Includes index.

Sommario/riassunto

This book constitutes the refereed proceedings of the 18th



International Conference on Ad-Hoc, Mobile, and Wireless Networks, ADHOC-NOW 2019, held in Luxembourg, in October 2019. The 37 full and 10 short papers presented were carefully reviewed and selected from 64 submissions. The papers provide an in-depth and stimulating view on the new frontiers in the field of mobile, ad hoc and wireless computing. They are organized in the following topical sections: IoT for emergency and disaster management; scheduling and synchronization in WSN; routing strategies for WSN; LPWANs and their integration with satellite; performance improvement of wireless and sensor networks; optimization schemes for increasing sensors lifetime; vehicular and UAV networks; body area networks, IoT security and standardization.