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1. |
Record Nr. |
UNINA9910346858503321 |
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Autore |
Neumann Dietbert |
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Titolo |
AMP-Activated Protein Kinase Signalling |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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Descrizione fisica |
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1 electronic resource (452 p.) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included. |
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2. |
Record Nr. |
UNINA9910877314803321 |
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Titolo |
Acetaldehyde-related pathology : bridging the trans-disciplinary divide / / [chair, Peter Emery] |
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Pubbl/distr/stampa |
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Chichester ; ; Hoboken, N.J., : John Wiley, 2007 |
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ISBN |
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1-280-85598-3 |
9786610855988 |
0-470-51184-2 |
0-470-51183-4 |
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Edizione |
[8th ed.] |
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Descrizione fisica |
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1 online resource (287 p.) |
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Collana |
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Novartis Foundation symposium ; ; 285 |
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Altri autori (Persone) |
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EmeryPeter <1953-> |
ChadwickDerek |
GoodeJamie |
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Disciplina |
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Soggetti |
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Acetaldehyde - Toxicology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Editors: Derek J. Chadwick and Jamie Goode. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide; Contents; Chair's introduction; Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes; Removal of acetaldehyde from the body; Acetaldehyde, polymorphisms and the cardiovascular system; Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models; Interrelationship between alcohol, smoking, acetaldehyde and cancer; Effects of acetaldehyde on human airway constriction and inflammation |
The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tractThe determination of acetaldehyde in exhaled breath; Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain; Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde; Alcoholic myopathy and acetaldehyde; Acetaldehyde adducts in circulation; General discussion; Pancreatic MAP kinase pathways and acetaldehyde; Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes |
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Endogenous a-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damageMeasurement of acetaldehyde: what levels occur naturally and in response to alcohol?; Final discussion; Contributors Index; Subject index |
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Sommario/riassunto |
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Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of |
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