Making Science Fun - A Tribute to Our Colleague and Friend, Prof. Antonius G. Rolink (1953-2017)

• Record Nr.: UNINA9910346754603321
• Autore: Rhodri Ceredig
• Pubbl/distr/stampa: Frontiers Media SA, 2019
• Descrizione fisica: 1 online resource (211 p.)
• Collana: Frontiers Research Topics
• Soggetti: Medicine and Nursing
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: This Research Topic honors the memory of Prof. Antonius "Ton" G. Rolink (April 19, 1953-August 06, 2017), our colleague, mentor and friend in immunology. It is now over a year since Ton left us. This article collection, authored by many of Ton's friends and colleagues, reflects the huge contribution to cellular and molecular immunology that work emanating directly from Ton's own hands and laboratory have made to the understanding of lymphocyte development. Ton's hard work, expertise, generosity, passion for science and infectious humor were legendary and for all of those lucky enough to have been his colleague, he ensured that science was fun. We take this opportunity of thanking all contributors for submitting their manuscripts; we are sure that Ton would have enjoyed reading and making his own insightful comments on them. In the form of original research and review articles, these papers cover many of Ton's scientific interests in different aspects of lymphocyte development in mouse and man. In the first section, Development of hematopoietic cells and lymphocytes, Klein et al. describe the accumulation of multipotent hematopoietic progenitors in peripheral lymphoid organs of IL-7xFlt3L double transgenic mice and Pang et al. the role of the transcription factor PU.1 on the development of Common Lymphoid Progenitors. In Early B cell development, Winkler and Mårtensson review the role of the Pre-B cell receptor in B cell development and papers by Hobeika et al. and Brennecke et al. describe models of inducible B cell ; development. For B cell selection, survival and tolerance, Smulski and Eibel review the role of BAFF and Kowalczyk-Quintans et al. analyse the role of membrane-bound BAFF. The impact of BIM on B cell homeostasis is discussed by Liu et al. The role of the MEK-ERK pathway in B cell tolerance is discussed by Greaves et al. and the transcriptional regulation of germinal center development is reviewed by Song and Matthias. For Hematological diseases, Ghia reviews how studies of B cell development help the understanding of Leukemia development, Kim and Schaniel review how iPS technology helps the understanding of hematological diseases and Hellmann et al. describe development of new therapeutic antibody drug conjugates. Finally, in T cell development, homeostasis and graft vs. host disease, Heiler et al. describe the therapeutic effects of IL-2/anti-IL-2 immune complexes in GvHD, Calvo-Asensio et al. describe the DNA damage response of thymocyte progenitors and Mori and Pieters review the role of Coronin 1 in T cell survival.

Conflict Resolution Beyond the International Relations Paradigm : Evolving Design as Transformative Practice in Nagorno-Karabakh and Syria / / Philip Gamaghelyan, Andreas Umland, Susan Allen

• Record Nr.: UNINA9910961621403321
• Autore: Gamaghelyan Philip
• Pubbl/distr/stampa: Hannover, : ibidem, 2017
• ISBN: 9783838270579; 3838270576
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (293 pages)
• Collana: Soviet and Post-Soviet Politics and Society
• Disciplina: 327.17
• Soggetti: Syria; conflict; resolution
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Table of Contents -- Abstract -- Acknowledgments -- Foreword -- Abbreviations -- Introduction -- Questions I am aiming to ; address -- The organization of the text -- Part I -- Chapter 1 Critical review of conflict resolution theories -- Binary frames in conflict resolution -- Realist theories of international relations -- Liberal theories of international relations -- In the shadow of Track 1: interactive problem solving -- Alternative to binary frames in conflict resolution -- Multitrack models of conflict resolution -- Network theory -- The third side -- Constructivist trends in conflict analysis -- Reflective and elicitive practice -- Theories of ethnicity and nationalism -- Critical theory -- Structuration theory: segue into participatory research design -- Chapter 2 Methodology -- Participatory action research -- Case selection -- Auto-ethnography -- First-person action research and collective auto-ethnography -- Second-person action research -- Ethical considerations and limitations -- Chapter 3 Auto-ethnographic sketch -- My background, the resulting perspective and subjectivity, and their role in this research -- Part II -- Chapter 4 On ethical and methodological challenges of leading a Syrian dialogue program in the middle of a civil war: from exclusion to inclusion -- The program design and implementation -- Program design vs. program reality -- Intermission -- Back to dialogue -- Methodological agony -- Reframing -- Getting real -- Closure -- Implications of the Syrian dialogue for this research: toward inclusive frames that do not privilege the violent extremes -- Chapter 5 On methodological challenges of leading an analytic initiative in the context of the long-lasting Nagorno-Karabakh conflict: from inclusion to exclusion -- The Nagorno-Karabakh Analytic Initiative -- The first meeting -- The first full symposium.; The second full symposium -- Working group -- Implications of the Nagorno-Karabakh Analytic Initiative for recognizing power dynamics and resulting exclusion, and marginalization -- Part II postscript -- Part III -- Chapter 6 Influence of macro-frames on conflict resolution practice. Addressing exclusion perpetuated by binary conflict discourses of international relations -- In the shadow of the international relations discourse -- Practical implications of naming initiatives "Track 2": impact on selection -- Practical implications of naming initiatives "Track 2": impact on dialogue -- Leaving the shadow: addressing patterns of marginalization influenced by the international relations discourse -- Conceptual alternatives -- Evolving Designs: rethinking the language of mediation -- Evolving Designs: rethinking dialogue and PSW -- Evolving Designs in practice: transforming the Analytic Initiative -- Chapter 6 postscript: gender and other binaries that affect conflict resolution practice -- Chapter conclusions -- Chapter 7 Marginalization specific to conflict resolution initiatives. Addressing the formation of dominant factions -- Formation of a single dominant faction within initiatives -- Cultural intelligibility to the organizers -- Reliance on a dominant discourse external to the initiative -- Competition for domination and shifting marginalization -- Recognizing and addressing domination and resulting marginalization -- Chapter conclusions -- Chapter 8 Addressing marginalization patterns within the conflict resolution community -- Competition among organizations -- Walking the talk: the case for the organizations preaching cooperation to lead by example -- Power struggles within teams -- Addressing marginalization within teams -- Chapter conclusions -- Chapter 9 Lessons learned -- Reflection: the learning and the key findings.; Action: Evolving Designs in Imagine Center's recent initiatives -- Questions for further research -- Postscript -- Bibliography -- Index.
• Sommario/riassunto: Conflict Resolution holds the promise of freeing approaches and policies with regard to politics of identity from the fatalistic grip of ; realism. While the conceptual literature on identity and conflicts has moved in this alternative direction, conflict resolution practice continues to rely on realist frames and acts as an unwanted auxiliary to traditional International Relations (IR). Perpetuation of conflict discourses, marginalization, and exclusion of affected populations are widespread. They are caused by the over-reliance of conflict resolution practice on the binary frames of classic IR paradigms and also by the competitive and hierarchical relationships within the field itself. Philip Gamaghelyan relies on participatory action research (PAR) and collective auto-ethnography to expose patterns of exclusion and marginalization as well as the paradoxical reproduction of conflict-promoting frames in current conflict-resolution practice applied to the Nagorno-Karabakh and Syrian crises. He builds on the work of post-modernist scholars, on reflective practice, and on discourse analysis to explore alternative and inclusive strategies with a transformative potential through reflections and actions customary for PAR. The IR discipline, that has dominated policy-making, is only one possible lens, and often a deficient one, for defining, preventing, or resolving contemporary conflicts wrapped in identity politics. Other conceptual frameworks can help to rethink our understanding of identity and conflicts and reconstruct them as performative and not static phenomena. These transformative frameworks are increasingly influential in the conflict resolution field and can be applied to policy-making.; Philip Gamaghelyan is an experienced scholar-practitioner whose authentic quest to transform international conflicts has resulted in discoveries that ought to occasion a fundamental paradigm shift in the field of conflict resolution. Gamaghelyan exposes and thoroughly documents how the field of international conflict resolution unwittingly perpetuates and reifies conflicts, rather than transforming them, as a consequence of the near-universal conceptual and/or practical assumption of conflict 'sides'. The very presumption that conflicts are characterized by 'sides' generates and maintains polarized and rigid oppositions while marginalizing any voices and constituencies that do not fit this oppositional framing. The author then documents how standard practices of international conflict resolution unintentionally create counter-productive marginalization across a range of additional dimensions, as well as how an emerging 'business' of conflict resolution profits from the maintenance of conflict. Through the sensitively and humbly narrated story of his own individual and collective learning through real-life cases of international conflict transformation processes, Gamaghelyan also provides insights and guidance for stepping into a new paradigm of international conflict transformation that, when authentically and self-critically engaged, creates new capabilities for genuinely resolving entrenched conflict. Dr. Jessica Srikantia, Rhodes Scholar and an Associate Professor at George Mason University’s Schar School of Policy and Government.