1.

Record Nr.

UNINA9910466765603321

Autore

Helmut Girndt (Editor)

Titolo

Das Nichts und das Sein, : Buddhistische Wissenstheorien und Transzendentalphilosophie

Pubbl/distr/stampa

Leiden, ; Boston : , : Brill, , 2018

ISBN

90-04-37568-6

Descrizione fisica

1 online resource (338 pages)

Collana

Fichte-Studien ; ; Band 46

Disciplina

141/.3

Soggetti

Transcendentalism

Knowledge, Theory of (Buddhism)

Mahayana Buddhism

Electronic books.

Lingua di pubblicazione

Tedesco

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Front Matter -- Inhaltsverzeichnis / Helmut Girndt -- Das Nichts und das Sein: Buddhistische Wissenstheorie und Transzendentalphilosophie / Helmut Girndt -- Geleitwort / Omine Akira -- Vorbemerkungen des Herausgebers / Helmut Girndt -- Über abendländische Verständnisgrundlagen des mahayana-buddhistischen Denkens / Lutz Geldsetzer -- Subjektivität und Transzendenz im Anattavāda / Martin Bunte -- Das Sein bei Fichte und die Leere im Mahayana-Buddhismus / Omine Akira -- Fichtes Philosophie des Seins und Nāgārjunas Philosophie der Leere / Helmut Girndt -- Der präreflexive Grund des Bewusstseins: Eine transzendentalphilosophische Interpretation Nāgārjunas / Fabian Völker -- Fichte und Nishida: Das Absolute und das absolute Nichts / Hitoshi Minobe -- Auf Nichts gebaut: Zum logischen Kern von Nishida Kitarōs Philosophie / Raji C. Steineck -- Wissen und Leben im Selbstsein / Kunihiko Nagasawa -- Leib und Handeln im Buddhismus: Erlösung durch Selbstgewahrung / Katsuki Hayashi -- Der Weg des Wissens, Vijñānavāda und die Transzendentalphilosophie Fichtes / Helmut Girndt -- Buddhistische Unbeständigkeitssicht und Nietzsches Nihilismus: Gemeinsamkeiten und Verschiedenheiten / Kogaku Arifuku -- Beiträge zur theoretischen Philosophie / Helmut Girndt -- Knowing, Creating and Teaching: Fichte’s Conception of Philosophy as Wissenschaftslehre / Luis Fellipe



Garcia -- Reines und Absolutes Wissen in der Wissenschaftslehre 1804-II / Valentin Pluder -- Ist die theoretische Vernunft selbst eine Idee? Fichtes Umgang mit Kantischen Ideen um 1810 / Michael Lewin -- Fichte über das Ich: Das Individuum und der überindividuelle Standpunkt in den Berliner Vorlesungen über die „Thatsachen des Bewußtseyns“ / Johannes Stoffers S.J. -- Lag Henrich falsch? Eine Fichte-konforme Interpretation von Hölderlins „Urteil und Sein“ / Saša Josifović.

Sommario/riassunto

Dreißig Jahre kollegialer Beziehung zwischen der Japanischen und der Internationalen Fichte Gesellschaft haben im Band 46 der Fichte Studien ihren Ausdruck gefunden, einer Sammlung von Aufsätzen auf der Grundlage transzendentaler Philosophie (Kants, Fichtes und Husserls) und klassischer Texte des Mahayana Buddhismus (und der japanischen Kyoto Schule). Ohne unvereinbare Unterschiede zwischen westlichem und östlichem Denken zu leugnen, finden sie ihre Grundlage in prä-reflexiver Erkenntnis. Beitragende sind Kogaku Arifuko, Martin Bunte, Luis Fellipe Garcia, Lutz Geldsetzer, Helmut Girndt, Katsuki Hayashi, Saša Josifović, Michael Lewin, Hitoshi Minobe, Kunihiko Nagasawa, Akira Omine, Valentin Pluder, Raji C. Steineck, Johannes Stoffers und Fabian Völker. Thirty years of friendly connections between the Japanese Fichte Association and the International Fichte Society have found expression in volume 46 of Fichte Studien . It contains a collection of comparative studies between European and Japanese philosophy centered on transcendental philosophy (of Kant, Fichte and Husserl) and classical Mahayana Buddhism (plus Japan´s Kyoto school). Without denying irreconcilable differences between western and eastern thinking these essays demonstrate that western as well as eastern thinking is based on the universal ground of pre-reflexive cognition.



2.

Record Nr.

UNINA9910345963903321

Autore

Michel Kranendonk

Titolo

Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition

Pubbl/distr/stampa

Frontiers Media SA, 2018

Descrizione fisica

1 online resource (152 p.)

Collana

Frontiers Research Topics

Soggetti

Pharmacology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Sommario/riassunto

Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations



altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms.