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1. |
Record Nr. |
UNISALENTO991002040319707536 |
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Autore |
Panzini, Franco |
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Titolo |
Progettare la natura : architettura del paesaggio e dei giardini dalle origini all'epoca contemporanea / Franco Panzini |
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Pubbl/distr/stampa |
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Bologna : Zanichelli, 2005 |
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ISBN |
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Edizione |
[1. ed.] |
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Descrizione fisica |
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xii, 372 p. : ill. ; 24 cm. |
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Soggetti |
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Giardini - Storia |
Paesaggi - Architettura - Storia |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Include bibliografia (p. 355-361) e indice. |
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2. |
Record Nr. |
UNINA9910338254103321 |
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Autore |
Daimon Takashi |
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Titolo |
Dose-Finding Designs for Early-Phase Cancer Clinical Trials : A Brief Guidebook to Theory and Practice / / by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui |
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Pubbl/distr/stampa |
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Tokyo : , : Springer Japan : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (146 pages) |
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Collana |
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JSS Research Series in Statistics, , 2364-0065 |
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Disciplina |
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Soggetti |
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Biometry |
Statistics |
Biostatistics |
Statistical Theory and Methods |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs. |
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Sommario/riassunto |
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This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This bookalso covers more complex and updated |
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dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on. |
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