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1. |
Record Nr. |
UNINA9910338011703321 |
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Autore |
Williams Mark |
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Titolo |
Expert Twisted : Event-Driven and Asynchronous Programming with Python / / by Mark Williams, Cory Benfield, Brian Warner, Moshe Zadka, Dustin Mitchell, Kevin Samuel, Pierre Tardy |
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Pubbl/distr/stampa |
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Berkeley, CA : , : Apress : , : Imprint : Apress, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (391 pages) |
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Disciplina |
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Soggetti |
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Python (Computer program language) |
Programming languages (Electronic computers) |
Python |
Programming Languages, Compilers, Interpreters |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Part 1: Foundations -- 1. Introduction to Event-Driven programming via Twisted -- 2. Introduction to Asynchronous Programming with Twisted -- 3. Practical Twisted Applications with treq and klein -- Part 2: Projects -- 4. Twisted and Docker -- 5. Twisted as a WSGI Container -- 6. Tahoe LAFS -- 7. Magic Wormhole -- 8. Autobahn -- 9. Integrating Twisted and Asyncio -- 10. Buildbot -- 11. HTTP2 -- 12. Twisted and Django Channels. |
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Sommario/riassunto |
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Explore Twisted, the Python-based event-driven networking engine, and review several of its most popular application projects. It is written by community leaders who have contributed to many of the projects covered, and share their hard-won insights and experience. Expert Twisted starts with an introduction to event-driven programming, explaining it in the context of what makes Twisted unique. It shows how Twisted's design emphasizes testability as a solution to common challenges of reliability, debugging, and start-to-finish causality that are inherent in event-driven programming. It also explains asynchronous programming, and the importance of functions, deferreds, and coroutines. It then uses two popular applications, treq |
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and klein, to demonstrate calling and writing Web APIs with Twisted. The second part of the book dives into Twisted projects, in each case explaining how the project fits into the Twisted ecosystem and what it does, and offers several examples to bring readers up to speed, with pointers to additional resources for more depth. Examples include using Twisted with Docker, as a WSGI container, for file sharing, and more. |
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2. |
Record Nr. |
UNINA9910298297203321 |
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Titolo |
Resistance to Aromatase Inhibitors in Breast Cancer / / edited by Alexey Larionov |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
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ISBN |
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Edizione |
[1st ed. 2015.] |
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Descrizione fisica |
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1 online resource (298 p.) |
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Collana |
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Resistance to Targeted Anti-Cancer Therapeutics, , 2196-5501 ; ; 8 |
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Disciplina |
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610 |
611.01816 |
614.5999 |
616.9041 |
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Soggetti |
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Cancer - Research |
Drug resistance |
Molecular biology |
Cancer Research |
Drug Resistance |
Molecular Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Preface; Acknowledgments; Contents; 1 Clinical Use of Aromatase Inhibitors in Breast Cancer: History and Present ; Abstract ; Abbreviations; Introduction; From Beatson to Aromatase Inhibitors; Current Situation; Neo-Adjuvant Setting; Adjuvant Setting; Advanced Disease; Resistance to Aromatase Inhibition; Conclusion; References; 2 |
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Structure, Regulation and Polymorphisms of the Aromatase Gene ; Abstract ; Abbreviations; Introduction: Tissue-Specific Expression of Human Aromatase; Structure of the Human Aromatase Gene; Expression of Aromatase in Breast Cancer Stroma |
Transcriptional Regulation of the Aromatase Gene in Breast Cancer TissuesEpigenetic Regulation of Aromatase; Genetic Polymorphisms of the Human Aromatase Gene Associated with AI Response and Susceptibility to Breast Cancer; Post-transcriptional Regulation of Aromatase; Other Possible Factors that Affect Aromatase; Conclusion; References; 3 Structure, Function and Inhibition of Aromatase ; Abstract ; Abbreviations; Introduction; Crystal Structure of Human Placental Aromatase; Architecture of the Active Site; Structural Perspective on the Mechanism of Action; Membrane Integration |
Oligomerization of AromataseRoles of Critical Residues; Motion and Flexibility of the Aromatase Molecule; Aromatase Inhibitors: Recent Developments; Phosphorylation of Aromatase and Estrogen Signaling: The New Frontier; Concluding Remarks; References; 4 In Vivo Models of AI Resistance ; Abstract ; Abbreviations; Introduction; Carcinogen Induced Syngeneic Tumor Model; Xenograft Model Using the Nude Mouse; Intra-tumoral Aromatase Xenograft Model; Aromatase Inhibitors as First Line Agents; AI Resistance Models; Estrogen Deprivation Based Models; LTED Model; UMB-1Ca Model |
Letrozole Resistance ModelTransplanted Tumors; Activation of Growth Factor Pathways; Other Models; Variations Between the Models of AI Resistance; Discrepancies Between Animal Models and Clinical Data; Conclusion; References; 5 Ineffective Inhibition of Aromatase: A Cause for AI Resistance? ; Abstract ; Abbreviations; Introduction; The Aromatase Enzyme and Estrogen Disposition in Postmenopausal Women; Plasma Estrogen Measurements in Relation to Treatment with Aromatase Inhibitors; Tracer Studies; Tissue Estrogen Levels; Conclusions; References |
6 Understanding the New Biology of Estrogen-Induced Apoptosis and Its Application in Patient Care Abstract ; Abbreviations; Introduction; Selective Estrogen Receptor Modulators (SERMs); Contribution of SERM Resistance in Understanding Estrogen-Induced Apoptosis; Long-Term Estrogen Deprivation; Molecular Mechanisms of Estrogen-Induced Apoptosis; Estrogen-Induced Apoptosis: Clinical Translation Opportunities; Perspectives and Conclusions; References; 7 Ligand-Independent Signalling Through Estrogen Receptor Pathways in Breast Cancer ; Abstract ; Abbreviations; Introduction |
Background: Classical Ligand-Dependent Estrogen Receptor Signalling |
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Sommario/riassunto |
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The book brings together current knowledge about molecular and clinical aspects of resistance to aromatase inhibitors (AIs). The topics and features include: The history of development and clinical role of aromatase inhibitors in breast cancer. The structure and function of aromatase gene and protein, including tissue-specific splicing and regulation of the gene, crystal structure of the enzyme, functioning of its active site and structural basis for development of new aromatase inhibitors. Experimental and pre-clinical models of resistance to aromatase inhibitors (including cell lines and xenografts) as well as methods and results of measuring oestrogen concentrations in blood and tumour tissue of breast cancer patients. Diversity of molecular mechanisms of AI resistance, including (i) ligand-independent signalling through oestrogen receptor pathway, (ii) hypersensitivity to low concentrations of oestrogens, (iii) crosstalk with non-endocrine signalling (including PI3K/mTOR, IGF, GDNF and Myc pathways), (iv) involvement of oestrogen-induced apoptosis and tissue microenvironment (including inflammatory immune cells and |
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adipocytes) as well as (v) the role of epigenetic mechanisms and pioneering factors in ER signalling and AI resistance. Molecular markers and multi-gene signatures to predict response to AIs, clinical trials aimed at preventing or overcoming resistance by combining AIs with novel targeted agents (including AI combinations with HER2, EGFR, mTOR, PI3K, Akt, CDK4/6, FGFR, HDAC, IGF-1, Src, proteosome- and angiogenic- targeting agents). A review of the effects and clinical indications of aromatase inhibitors beyond breast cancer. Many of the chapters provide extensive historical overviews to connect current knowledge with the history and inner logic of the field. The authors’ team includes world-leading experts, making the book an essential resource for scientists developing new treatments for breast cancer and for medics treating breast cancer patients with aromatase inhibitors. |
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