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1. |
Record Nr. |
UNINA9910416107703321 |
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Titolo |
Next Generation Kinase Inhibitors : Moving Beyond the ATP Binding/Catalytic Sites / / edited by Paul Shapiro |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (XII, 217 p. 59 illus., 56 illus. in color.) |
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Disciplina |
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Soggetti |
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Cancer - Research |
Cancer Research |
Proteïnes quinases |
Llibres electrònics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index. |
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Sommario/riassunto |
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Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about |
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how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. . |
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2. |
Record Nr. |
UNINA9910337878403321 |
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Autore |
Niemz Markolf H |
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Titolo |
Laser-Tissue Interactions : Fundamentals and Applications / / by Markolf H. Niemz |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[4th ed. 2019.] |
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Descrizione fisica |
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1 online resource (XVIII, 313 p. 180 illus., 77 illus. in color.) |
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Disciplina |
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Soggetti |
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Biophysics |
Surgery |
Lasers |
Photonics |
Quantum optics |
Manufactures |
Biological and Medical Physics, Biophysics |
Optics, Lasers, Photonics, Optical Devices |
Quantum Optics |
Manufacturing, Machines, Tools, Processes |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- Historical Review -- Goal of the Book -- Outlook -- Light and Matter -- Reflection and Refraction -- Absorption -- Scattering -- Turbid Media -- Photon Transport Theory -- |
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Measurement of Optical Tissue Properties -- Questions to Chapter 2 -- Interaction Mechanisms -- Photochemical Interaction -- Photothermal Interaction -- Photoablation -- Plasma-Induced Ablation -- Photodisruption -- Questions to Chapter 3 -- Medical Applications of Lasers -- Lasers in Ophthalmology -- Lasers in Dentistry -- Lasers in Gynecology -- Lasers in Urology -- Lasers in Neurosurgery -- Lasers in Angioplasty and Cardiology -- Lasers in Dermatology -- Lasers in Orthopedics -- Lasers in Gastroenterology -- Lasers in Otorhinolaryngology and Pulmology -- Questions to Chapter 4 -- Laser Safety -- Introduction -- Laser Hazards -- Eye Hazards -- Skin Hazards -- Associated Hazards from High Power Lasers -- Laser Safety Standards and Hazard Classification -- Viewing Laser Radiation -- Eye Protection -- Laser Beam Calculations -- Questions to Chapter 5 -- Solutions. . |
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Sommario/riassunto |
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Laser-Tissue Interactions by Prof. Dr. Markolf H. Niemz (Heidelberg University) has become the standard reference book in this fast growing field. It addresses basic concepts such as optical and thermal tissue properties, hard and soft tissue ablation, and photobiomodulation. Clinical applications are reviewed according to the latest references. The last chapter covers today's standards of laser safety with a careful selection of essential guidelines published by the Laser Institute of America. This fourth edition has been completely revised and updated. Color illustrations, summaries, and questionnaires with solutions transform this book into a useful guide for graduate students, scientists, and medical practitioners. OPHTHALMOLOGY DENTISTRY GYNECOLOGY UROLOGY NEUROSURGERY ANGIOPLASTY AND CARDIOLOGY ORTHOPEDICS DERMATOLOGY AND COSMETICS GASTROENTEROLOGY OTORHINOLARYNGOLOGY “An extremely useful reference companion.” LASERS IN SURGERY AND MEDICINE. |
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