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Record Nr. |
UNINA9910136401503321 |
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Autore |
M Foster Olive |
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Titolo |
Neuronal and glial structural plasticity induced by drugs of abuse / / edited by: M. Foster Olive and Justin Gass |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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[Lausanne, Switzerland] : , : Frontiers Media SA, , 2015 |
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©2015 |
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Descrizione fisica |
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1 online resource (90 pages) : illustrations ( some colour); digital file(s) |
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Collana |
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Frontiers Research Topics |
Frontiers in Pharmacology |
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Soggetti |
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Brain - Effect of drugs on |
Neuroplasticity |
Neuropharmacology - Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons, as drugs of abuse also induce molecular and cellular alterations in various glial cell types such as astrocytes and microglia. This drug-induced "rewiring" of the brain at numerous levels can contribute to the development, maintenance, and persistence of the addicted state, as well as associated deficits in normal cognitive functioning. The aim of this Research Topic is to collect recent and important findings related to the structural alterations produced by drug of abuse in neurons, glial, and other cell types of the central nervous system. Suitable areas of analysis include but are not limited to: macrostructure of individual brain regions, dendritic branching and architecture, dendritic spine density and morphology, cell soma morphology, presynaptic terminal volume, astrocytic process length and branching, myelination, and microglial |
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2. |
Record Nr. |
UNINA9910337849303321 |
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Autore |
Waguespack Leslie J |
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Titolo |
Designing Thriving Systems : Marrying Technical Rationality and Appreciative Systems / / by Leslie J. Waguespack |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (248 pages) |
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Disciplina |
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Soggetti |
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Computer programming |
User interfaces (Computer systems) |
Design |
Computers |
Cognitive psychology |
Psychology, Applied |
Programming Techniques |
User Interfaces and Human Computer Interaction |
Design, general |
Models and Principles |
Cognitive Psychology |
Applied Psychology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- The Brain of Two Hemispheres -- A Marriage of Technical Rationality And Appreciative Systems -- Reflection-Driven Design -- Generative Metaphor: Names, Frames and Concept Displacement -- Ontological Depictions of Design Space -- Thriving Systems Choice Properties Extruded through Mediums of Construction -- Security Design Quality Named and Framed though TST Choice Property Clusters -- Educating Thriving Systems Designers. . |
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Sommario/riassunto |
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This monograph illuminates a design mindset for systems, artefacts, that not only survive, but thrive. Of itself an artefact is devoid of design quality – until encountered in a specific social context by human attendants. Design quality is the affect of an intertwining of (a) an artefact’s structural and behavior properties, (b) an attendant humanly conception of quality, an appreciative system, and (c) the enfolding social context of their encounter. To pursue quality in design is to interweave these three strands bound as a durable cord that evokes a visceral satisfaction – or “the delight of a ringing musical chord.” The human consciousness of design quality is fundamentally metaphoric and dynamic – a perception of reality mediated by a personal value disposition. In the continuum of experience, living moment after moment, both the attendant’s metaphorical appreciation and their sense of quality evolve. And thus, design quality issues from perpetual, concentric cycles of design-construct-experience-learn-assess-calibrate over the life span of relationship with an artefact. Design-as-a-verb’s purpose is to service the life in that relationship, sustain its survival, and hopefully, raise that life to a state of thriving. Design quality manifests throughout the cycles of design-as-a-verb, rather than as a product of it. Such is the mindset in which the designer must indwell and that design education must nurture. While all artefacts are systems, the domain of artefact design of which I am most experienced is computing systems. Therefore, I will rest upon that domain to explore a theory and practice of design-as-a-verb – designing thriving systems. |
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