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1. |
Record Nr. |
UNINA9910337570903321 |
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Autore |
Mangul Serghei |
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Titolo |
Hidden Treasures in Contemporary RNA Sequencing / / by Serghei Mangul, Harry Taegyun Yang, Eleazar Eskin, Noah Zaitlen |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (99 pages) |
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Collana |
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SpringerBriefs in Computer Science, , 2191-5768 |
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Disciplina |
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Soggetti |
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Bioinformatics |
Genetics |
Computational Biology/Bioinformatics |
Genetics and Genomics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Abstract -- Main Text -- Acknowledgement -- Disclosure -- References. |
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Sommario/riassunto |
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Advances in RNA-sequencing (RNA-seq) technologies have provided an unprecedented opportunity to explore the gene expression landscape across individuals, tissues, and environments by efficiently profiling the RNA sequences present in the samples. When a reference genome sequence or a transcriptome of the sample is available, mapping-based RNA-seq analysis protocols align the RNA-seq reads to the reference sequences, identify novel transcripts, and quantify the abundance of expressed transcripts. The reads that fail to map to the human reference, known as unmapped reads, are a large and often overlooked output of standard RNA-seq analyses. Even in carefully executed experiments, the unmapped reads can comprise a considerable fraction of the complete set of reads produced, and can arise due to technical sequencing produced by low-quality and error-prone copies of the nascent RNA sequence being sampled. Reads can also remain unmapped due to unknown transcripts, recombined B and T cell receptor sequences, A-to-G mismatches from A-to-I RNA editing, |
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trans-splicing, gene fusion, circular RNAs, and the presence of non-host RNA sequences (e.g. bacterial, fungal, and viral organisms). Unmapped reads represent a rich resource for the study of B and T cell receptor repertoires and the human microbiome system—without incurring the expense of additional targeted sequencing. This book introduces and describes the Read Origin Protocol (ROP), a tool that identifies the origin of both mapped and unmapped reads. The protocol first identifies human reads using a standard high-throughput algorithm to map them onto a reference genome and transcriptome. After alignment, reads are grouped into genomic (e.g. CDS, UTRs, introns) and repetitive (e.g. SINEs, LINEs, LTRs) categories. The rest of the ROP protocol characterizes the remaining unmapped reads, which failed to map to the human reference sequences. |
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2. |
Record Nr. |
UNINA9910254917203321 |
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Autore |
Kahlout Gabriele |
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Titolo |
Spinning up ServiceNow : IT service managers' guide to successful user adoption / / Gabriele Kahlout |
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Pubbl/distr/stampa |
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New York : , : Apresss, , 2017 |
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Edizione |
[1st ed. 2017.] |
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Descrizione fisica |
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1 online resource (xvii, 241 p.) : ill |
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Classificazione |
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Disciplina |
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Soggetti |
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Management information systems |
Computers, Special purpose |
Business IT Infrastructure |
Special Purpose and Application-Based Systems |
computer applications |
software |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Part I: ITSM in the Real World -- Chapter 1: Pragmatic or Tragic ITSM -- Chapter 2: Innovators' ITSM Strategy -- Part II: Essentials -- Chapter 3: User Access -- Chapter 4: Email Support -- Chapter 5: Elegant |
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Notifications -- Chapter 6: Request Portal -- Chapter 7: Reporting -- Part III: After Go-Live -- Chapter 8: Customization Process -- Chapter 9: Confidentiality -- Chapter 10: Fluid Collaboration -- Chapter 11: More Customization Examples -- Chapter 12: ServiceNow Jargon -- Part IV: Appendices -- Chapter 13: Appendix A: Checks and Monitors -- Chapter 14: Appendix B: Access Requirements -- . |
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Sommario/riassunto |
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This book teaches IT service managers how to onboard ServiceNow ITSM tools by evangelizing, educating, and coordinating their organization's service desk, developers, and stakeholders. Drawing on his own story of lessons learned in spinning up the adoption of ServiceNow throughout the Al Jazeera Media Network, application architect Gabriele Kahlout shows IT service managers how to launch automated ServiceNow ticketing tools in seamless integration with their organization's existing email and Active Directory. Spinning Up ServiceNow: IT Service Managers Guide to Successful User Adoption shows IT service managers how to orchestrate their IT service desks and developers to facilitate the adoption and consumption of IT services by all users, supporting their various business needs while optimizing human-computer interaction and minimizing stress and productivity loss arising from poor human-system design. What you will learn: How to quick-start ServiceNow in a matter of days with the minimum configuration required to start processing tickets via email How to avoid the teething problems that can spoil your users’ onboarding experience with ServiceNow How to automate the process of scaling up new teams into ServiceNow How to shape your users' experiences so that they retain their familiar bearings in email and Active Directory while welcoming the power of ServiceNow enhancements How to create a strategy to avoid common pitfalls that sabotage ITSM programs. |
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