Colonial Kenya observed : British rule, Mau Mau and the wind of change / / S. H. Fazan; edited and with a foreword by John Lonsdale

• Record Nr.: UNINA9910511996803321
• Autore: Fazan S. H. <1888-1979, >
• Pubbl/distr/stampa: London : , : I.B. Tauris, , 2015; ©2015
• ISBN: 0-7556-2415-7; 0-85773-784-8
• Descrizione fisica: 1 online resource (331 p.)
• Disciplina: 967.62/03
• Soggetti: Biography: historical, political & military; Great Britain Colonies Africa Administration; Kenya History Mau Mau Emergency, 1952-1960; Kenya Politics and government To 1963
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Completed in 1969; not previously published.
• Nota di bibliografia: Includes bibliographical references (pages 341-351) and index.
• Nota di contenuto: Part 1. British East Africa. Historical background -- Early days of the Protectorate -- First impressions -- Races and migrations -- The First World War. -- ; Part 2. The Colony during the inter-war years. The coast -- Principal events and politics -- Changes. -- ; Part 3. Government in the African lands. The field administration -- African authorities. -- ; Part 4. Land. Agrarian problems of the African lands -- The white highlands. -- ; Part 5. The later colonial period. The Second World War -- Post-war settlement and Kikuyu politics -- The Mau Mau revolt -- Economic development. -- Part 6. Towards independence. The Lancaster House Conference and the end of the colony -- The wind of change. ; Appendix 1: Policy and theory -- ; Appendix 2: African laws and customs -- ; Appendix 3: An economic survey of the Kikuyu reserves.
• Sommario/riassunto: "The coast of East Africa was considered a strategically invaluable region for the establishment of trading ports, both for Arab and Persian merchants, long prior to invasion and conquest by Europeans. In the initial stages of the scramble for Africa in the 18th century, control of the area was an aspiration for every colonial nation in Europe - but it ; was not until 1895 that it was finally dominated by a sole power and proclaimed The Protectorate of British East Africa. In the early 20th century, the coast was brimming with vitality as immigrants, colonisers and missionaries from Arabia, India and Europe poured in to take advantage of growing commercial opportunities - including the prospect of enslaving millions of native Africans. The development of Kenya is an exceptional tale within the history of British rule - in perhaps no other colony did nationalistic feeling evolve in conditions of such extensive social and political change. In 1911, S.H. Fazan sailed to what later became the Republic of Kenya to work for the colonial government. Immersing himself in knowledge of traditional language and law, he recorded the vast changes to local culture that he encountered after decades of working with both the British administration and the Kenyan people. This work charts the sweeping tide of social change that occurred through his career with the clarity and insight that comes with a total intimacy of a country. His memoirs examine the fascinating complexity of interaction between the colonial and native courts, commercial land reform and the revolutionised dynamic of labour relations. By further unearthing the political tensions that climaxed with the Mau Mau Revolt of 1952-1960, this invaluable work on the European colonial period paints a comprehensive and revealing firsthand account for anyone with an interest in British and African history. Fazan's story provides a quite unparalleled view of colonial Africa and the conduct of Empire across half a century."--Bloomsbury publishing.

Complementary Metal Oxide Semiconductor / / edited by Kim Ho Yeap and Humaira Nisar

• Record Nr.: UNINA9910317801903321
• Pubbl/distr/stampa: Croatia : , : IntechOpen, , 2018
• ISBN: 1-83881-512-0; 1-78923-497-2
• Descrizione fisica: 1 online resource (162 pages) : illustrations
• Disciplina: 621.3815284
• Soggetti: Metal oxide semiconductor field-effect transistors
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references.

Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity

• Record Nr.: UNINA9911028670903321
• Autore: Carey Jannette
• Pubbl/distr/stampa: Newark : , : John Wiley & Sons, Incorporated, , 2025; ©2026
• ISBN: 1-394-34294-2; 1-119-87847-0
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (307 pages)
• Disciplina: 572.33
• Soggetti: Ligand binding (Biochemistry)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Cover -- Title Page -- Copyright -- Contents -- About the Cover -- Introduction -- Chapter 1 The Biology of Molecules -- Why Study ; Intermolecular Interactions Quantitatively? -- Equilibrium and Kinetics -- Thermodynamic Definitions of Affinity and Specificity -- The Affinity/Specificity Map -- Biology Requires Optimization of Affinity and Specificity -- The Special Case of Protein‐DNA Interactions -- Chapter 2 General Theory for Reversible Ligand Binding -- Definition of Ligand and Titration -- Affinity, Specificity, Stoichiometry, and Cooperativity -- Ligand‐binding Theory: Relationship to Experiment -- General Theory for Reversible Ligand Binding: Rooted in Chemical Equilibrium -- General Theory for Reversible Ligand Binding: Quantitative Treatment -- The Case of 1:1 Binding -- General Theory for Reversible Ligand Binding: Conservation of Mass -- Definition of ν‾ -- The Basic Equation for 1:1 Binding -- The Single Most Important Thing You Can Learn in This Book -- The Example of Heme Binding to Apocytochrome C -- The Rectangular Hyperbola -- The Binding Isotherm -- Plot of ν‾ vs. [Hf] -- General Theory for Reversible Ligand Binding: Role of Mass Action -- Plot of [AH] vs. [Ht] with Fixed K -- Determination of Kd from Experiment -- Plot of [AH] vs. [Ht] with Fixed [At] -- Determining Molar Ratio from Experiment -- About Activity -- Chapter 3 Graphical Analysis -- Limitations of Direct Plots -- The Semi‐log Plot -- Breadth of the Semi‐log Plot -- Myoglobin and Hemoglobin -- Advantages of the Direct and Semi‐log Plots of Binding Data -- Linear Transforms of the Basic Binding Equation -- Common Linearizations -- Requirements of the Linear Regression Model -- A Linear Model May Misrepresent the Physical Process -- Deviations from Linearity Are Hard to Detect or Interpret -- Linear Transforms Distort Data Completeness.; Linear Transforms Invite - Even Require - Extrapolation -- Linear Transforms Falsely Promise Both K and Molar Ratio from a Single Dataset -- Summary about Linear Treatments of Binding Data -- Simulation Is Just as Good as Fitting, Given Realistic Experimental Errors -- Chapter 4 Binding of Multiple Ligands -- Conservation of Mass Outside the 1:1 Case -- Redefine ν&lt -- 3:mo 0:stretchy&amp -- equals -- "true" &gt -- ‾ to Accommodate Any Molar Ratio -- Accounting for the Definition of Molecule -- Generalizing to Integer Multiples of 1:1 -- The Langmuir Equation for Any Molar Ratio with Sites of Identical Affinity and No Cooperativity -- Adair Equation for Any Number of Binding Events -- The Langmuir Equation vs. the Adair Equation -- Thermodynamic Linkage -- Two Classes of Sites with Different Affinities -- Binding Isotherms for Multiple Sites with Different Affinities -- Summary -- Chapter 5 How to Determine Kd and Molar Ratio Experimentally -- Stoichiometric Titration First -- Amounts of Materials -- Assigning Partners -- Choice of Experimental Observables -- Choosing Solution Conditions -- How Many Data Points? -- Range‐Finding Stoichiometric Titration -- Visualizing Results -- Range‐Finding Asymptotic Titration to Estimate Kd -- Data Analysis -- Practicalities about Experimental Error -- Statistical Approaches to Estimate the Breakpoint -- Refined Asymptotic Titration -- Designing an Experiment to Refine Kd -- Calculating Free Ligand Concentration -- Refining the Value of Molar Ratio -- Example of ArgR/DNA Binding -- Plotting the Data -- Deriving Kd from the Data -- Summary -- Chapter 6 Cooperativity -- Facilitated and Antagonized Binding -- Free Energy Definition of Cooperative Binding -- Chemical Potential Diagram for Cooperative Binding -- Cooperativity as Non‐additivity -- Reciprocity of Cooperative Effects.; Limitations of Linear Transforms for Cooperative Interactions -- Microscopic View of Species Distribution -- Homotropic and Heterotropic Cooperativity -- Cooperativity Affects Specificity as Well as Affinity -- Cooperativity Is the Third Axis of the Affinity/Specificity ; Map -- Quantifying Homotropic Cooperativity -- Negative Homotropic Cooperativity -- A Practical Advantage of Negative Cooperativity -- Positive Cooperativity and the Ligand Concentration Interval -- Importance of Individual‐site Isotherms and Species Distribution -- Species Distributions by Specialized Experimental Methods -- The Many Forms of Cooperativity -- Emergent Properties -- Connectivity and Search Entropy -- Breakdown of Additivity in Complex Systems -- Statistical Effects -- Relevance of Non-additivity for Analysis of Mutations -- Universality and Promiscuity of Cooperativity -- Proteins as Gestalt Objects -- Summary -- Chapter 7 Theoretical and Method‐specific Troubleshooting -- Equilibrium and Nonequilibrium Methods -- Accessible Concentration Ranges Limit Accessible Kd Values -- Signal from Ligand or Target? -- Separation‐based Methods -- Filter Binding -- Gel Retardation or EMSA -- Gel Filtration -- Hummel and Dreyer Chromatography -- Equilibrium Dialysis -- UV Absorbance -- CD Spectroscopy -- Fluorescence -- NMR -- ITC -- AUC -- SPR -- MS -- Chapter 8 Allostery -- An Historical Overview -- Facilitated Binding -- Elaboration of the MWC Model -- Relaxed Monomers and Tense Multimers -- Positive Homotropic Cooperativity Only -- Artifactual Origins of Affinity Heterogeneity -- Relaxation of Multimers by Ligand Binding -- Koshland's Sequential (Asymmetric) Model -- G3Pase Was Heterogeneous, Not Negatively Cooperative -- Many Models Fit the Hemoglobin Data -- Advantages of Negative Cooperativity for Molecular Insight -- Biology of Negative Cooperativity.; Structural Analysis Cannot Solve Allostery -- Allostery without Cooperativity -- Summary -- Chapter 9 Lessons on Affinity and Specificity from Host/Guest Chemistry -- 2D Representations of 3D Objects -- Early Hosts Were Linear and Flexible -- Design of Molecular Properties -- Very Weak Affinity and No Detectable Specificity -- Later Hosts Pre‐organized in Bound Conformation -- Enormous Gains in Affinity and Specificity -- Bonds between Host and Guest Are Identical -- Lessons from the Host/Guest Chemistry -- Rational Design of Affinity and Specificity -- Affinity and Specificity Accrue in Parallel -- Cryptic Contributions Can Dominate Binding -- Chapter 10 Reconciling Structure and Thermodynamics in Molecular Interactions -- Thermodynamics of Molecular Interactions -- Structural Analysis of Bonding Does Not Predict Binding -- The Goldilocks Region of Affinity/Specificity Space -- Conformational Rearrangement upon Binding Decouples Affinity and Specificity -- A Reservoir of Adaptability -- No Simple Reconciliation of Structural and Energetic Views -- Implications for Drug Design -- Chapter 11 Applications in Modern Drug Development -- Background -- Technological Developments -- Crystal Structures -- Trapped High‐energy States -- Another Example -- Computational Methods -- High‐throughput Assays -- Druggability -- Irrational Drug Design -- A New Workflow -- Appendix A Ligand‐binding Study Questions -- Appendix B Thought Experiments -- Appendix C Derivations -- Appendix D Simulation and Fitting -- Simulation -- Fitting -- Appendix E About the Hill Equation -- Deriving the Hill Equation -- The Hill Equation as a Limit of the Adair Equation -- On Applying the Hill Equation to Quantify Cooperativity -- Appendix F Stereo Viewing -- Bibliography -- Index -- EULA.
• Sommario/riassunto: A concise and accessible textbook covering ligand-binding theory in chemistry, biology, and drug development In Ligand-binding Basics: Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity , accomplished chemist Professor Jannette Carey introduces ligand binding in a thorough and practical way for those new.