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Record Nr. |
UNINA9910315241903321 |
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Autore |
Rouveret Alain |
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Titolo |
Arguments minimalistes : Une présentation du Programme Minimaliste de Noam Chomsky / / Alain Rouveret |
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Pubbl/distr/stampa |
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Lyon, : ENS Éditions, 2016 |
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ISBN |
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2-84788-771-7 |
2-84788-684-2 |
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Descrizione fisica |
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1 online resource (448 p.) |
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Soggetti |
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Linguistics |
Minimalist Program |
principles and parameters |
interfaces |
third factor |
duality of sementics |
externalization |
principes et paramètres |
facteur 3 |
dualité de la sémantique |
externalisation |
interface |
Chomsky (Noam) |
linguistique |
grammaire générative |
programme minimaliste |
syntaxe |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Arguments minimalistes est une présentation systématique et détaillée du Programme Minimaliste défini par Noam Chomsky il y a une vingtaine d’années et qui n’a cessé d’évoluer depuis. Le livre dresse un |
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état des lieux de la théorie générative d’aujourd’hui, en prenant pour point de départ les textes de Chomsky lui-même. Le minimalisme inaugure une nouvelle façon de penser syntaxiquement et il vaut la peine d’examiner en détail les arguments que Chomsky invoque à l’appui de ce nouveau programme, qui met l’accent sur un ensemble de facteurs relativement ignorés dans les modèles précédents, mais qui doivent être, selon Chomsky, pris en compte prioritairement quand on cherche à construire une théorie du langage pleinement adéquate, allant au delà de l’adéquation explicative. Le fait que le langage soit en relation d’interface avec d’autres systèmes cognitifs auxquels il doit livrer des représentations lisibles, la nécessité de représenter la dualité de la sémantique, celle de linéariser les objets structuralement complexes produits par le mécanisme computationnel sont autant de dimensions qui contribuent nécessairement à façonner la Faculté de Langage et doivent intervenir dans la construction des grammaires. Cette synthèse, qui vise aussi à familiariser le lecteur avec les techniques d’analyse minimaliste, s’adresse aux étudiants avancés et aux linguistes confirmés, intéressés par la syntaxe et par les modèles formels en linguistique. Arguments minimalistes (Minimalist Arguments) is a state-of-the-art detailed and systematic introduction to the Minimalist Program, which was proposed by Chomsky twenty years ago and has been evolving ever since. The book reviews the current state of generative theory by taking Chomsky’s texts as a starting point. Minimalism introduces a new way of thinking syntactically and it is worth examining in detail the arguments that Chomsky puts forth in support of this new program, which places the emphasis on a set of factors that were… |
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2. |
Record Nr. |
UNINA9910136401403321 |
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Autore |
Tarik Issad |
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Titolo |
30 years old : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / / edited by Tony Lefebvre and Tarik Issad |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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Switzerland : , : Frontiers Media SA, , 2007-2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (113 pages) : illustrations |
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Collana |
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Frontiers Research Topics |
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Disciplina |
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Soggetti |
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Cell signalling |
Metabolism |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, |
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circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart. |
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