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1. |
Record Nr. |
UNINA9910300439403321 |
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Titolo |
Precision Molecular Pathology of Liver Cancer / / edited by Chen Liu |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
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ISBN |
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Edizione |
[1st ed. 2018.] |
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Descrizione fisica |
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1 online resource (XI, 271 p. 30 illus., 22 illus. in color.) |
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Collana |
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Molecular Pathology Library, , 1935-987X |
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Disciplina |
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Soggetti |
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Pathology |
Gastroenterology |
Oncology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Overview: Current diagnosis and treatment of HCC in the era of precision medicine -- The etiology and pathogenesis of hepatocellular carcinoma -- Histological classification of HCC and its clinical implication -- Molecular classification of HCC and precision medicine -- Recent advances in HCC genomics, next generation sequencing, and bioinformatics -- Epigenetic regulations in the pathogenesis of HCC and the clinical application -- Biomarker discovery and validation in HCC diagnosis, prognosis, and therapy -- HCC cancer stem cell signaling pathway -- Epithelial and mesenchymal transition (EMT) and its biological significance in HCC -- HCC metastasis and circulating tumor cells -- Biological role and potential clinical application of miRNA in hepatocellular carcinoma -- Immune regulation in HCC and the prospect of immunotherapy -- Liver cell dysplasia and the development of HCC -- Molecular pathogenesis of hepatic adenoma and its malignant transformation -- The role of liver biopsy in HCC early diagnosis and treatment decision -- The future prospect on surgical approaches for HCC -- The future prospect on targeted therapy for HCC. . |
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Sommario/riassunto |
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This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics |
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covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma. . |
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2. |
Record Nr. |
UNINA9910143884103321 |
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Titolo |
Engineering Societies in the Agents World III : Third International Workshop, ESAW 2002, Madrid, Spain, September 16-17, 2002, Revised Papers / / edited by Paolo Petta, Robert Tolksdorf, Franco Zambonelli |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2003 |
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ISBN |
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Edizione |
[1st ed. 2003.] |
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Descrizione fisica |
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1 online resource (X, 290 p.) |
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Collana |
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Lecture Notes in Artificial Intelligence ; ; 2577 |
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Disciplina |
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Soggetti |
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Artificial intelligence |
Computer networks |
Computer programming |
Software engineering |
Artificial Intelligence |
Computer Communication Networks |
Programming Techniques |
Software Engineering |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Views -- A Discussion of Two Major Benefits of Using Agents in Software Development -- Signs of a Revolution in Computer Science |
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and Software Engineering -- Models -- Rationality, Autonomy and Coordination: The Sunk Costs Perspective -- A Normative and Intentional Agent Model for Organisation Modelling -- Simulating Computational Societies -- Co-Fields: Towards a Unifying Approach to the Engineering of Swarm Intelligent Systems -- A Schema for Specifying Computational Autonomy -- Activity Theory as a Framework for MAS Coordination -- An Operational Framework for the Semantics of Agent Communication Languages -- Access-as-you-need: A Computational Logic Framework for Accessing Resources in Artificial Societies -- Motivating Participation in Peer to Peer Communities -- Engineering -- ADELFE: A Methodology for Adaptive Multi-agent Systems Engineering -- Evaluating Multi-agent System Architectures: A Case Study Concerning Dynamic Resource Allocation -- Engineering Agent Systems for Decision Support -- Co-ordinating Heterogeneous Interactions in Systems Composed of Active Human and Agent Societies -- Modelling and Design -- SABPO: A Standards Based and Pattern Oriented Multi-agent Development Methodology -- Modelling a Multi-agent System Environment -- Towards a Methodology for Coordination Mechanism Selection in Open Systems -- Specification by Refinement and Agreement: Designing Agent Interaction Using Landmarks and Contracts -- An Agent and Goal-Oriented Approach for Virtual Enterprise Modelling: A Case Study. |
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Sommario/riassunto |
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The characteristics of software systems are undergoing dramatic changes. We are moving rapidly into the age of ubiquitous information services. Persistent computing systems are being embedded in everyday objects. They interact in an autonomous way with each other to provide us with increasingly complex services and functionalities that we can access at any time from anywhere. As a consequence, not only do the numbers of components of software systems increase; there is also a strong qualitative impact. Software systems are increasingly made up of autonomous, proactive, networked components. These interact with each other in patterns and via mechanisms that can hardly be modeled in terms of classical models of interaction or service-oriented coordination. To some extent, future software systems will exhibit characteristics making them more resemblant of natural systems and societies than of mechanical systems and software architectures. This situation poses exciting challenges to computer scientists and software engineers. Already, software agents and multi-agent systems are recognized as both useful abstractions and effective technologies for the modeling and building of complex distributed applications. However, little is done with regard to effective and methodic development of complex software systems in terms of multi-agent societies. An urgent need exists for novel approaches to software modeling and software engineering that enable the successful deployment of software systems made up of a massive number of autonomous components, and that allow us to control and predict their behaviour. |
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