1.

Record Nr.

UNINA9910300426803321

Autore

Karschau Jens

Titolo

Mathematical Modelling of Chromosome Replication and Replicative Stress / / by Jens Karschau

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015

ISBN

3-319-08861-0

Edizione

[1st ed. 2015.]

Descrizione fisica

1 online resource (89 p.)

Collana

Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053

Disciplina

572.8645

Soggetti

Biophysics

Statistical physics

Dynamics

Nucleic acids

Genetic engineering

Physics

Biological and Medical Physics, Biophysics

Complex Systems

Nucleic Acid Chemistry

Genetic Engineering

Numerical and Computational Physics, Simulation

Statistical Physics and Dynamical Systems

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references at the end of each chapters.

Nota di contenuto

Introduction -- Optimal Origin Placement for Minimal Replication Time -- Actively Replicating Domains Randomly Associate into Replication Factories -- Summary and Conclusions.

Sommario/riassunto

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next, and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.   This work makes important contributions to this line of research. In



particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome; and how is the spatial organization of replication factories achieved inside the nucleus of a cell?   A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.