1.

Record Nr.

UNINA9910300407303321

Autore

Bittihn Philip

Titolo

Complex Structure and Dynamics of the Heart / / by Philip Bittihn

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015

ISBN

3-319-12232-0

Edizione

[1st ed. 2015.]

Descrizione fisica

1 online resource (214 p.)

Collana

Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053

Disciplina

530

530.1

571.4

616.12

Soggetti

Biophysics

Biological physics

Statistical physics

Cardiology

Physics

Biological and Medical Physics, Biophysics

Applications of Nonlinear Dynamics and Chaos Theory

Numerical and Computational Physics, Simulation

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Introduction -- Methods -- Results -- Conclusion -- Appendix A Modeling Details -- Appendix B Supplementary Data -- Appendix C MediaSim -- An Open Framework for Simulating Extended Systems -- Index.

Sommario/riassunto

This award-winning thesis investigates the mechanisms underlying cardiac arrhythmia development and termination from an entirely new perspective. By viewing the heart as a complex system, the author uses theoretical tools from nonlinear dynamics combined with numerical simulations and experiments to achieve insights into the relationship between its structure and dynamics, thereby paving the way towards innovative low-energy defibrillation strategies. The work tackles,



among other things: the effect of substrate heterogeneity on the spatial-temporal dynamics of cardiac arrhythmias and ways in which weak pulsed electric fields can be used to control these dynamics in heterogeneous cardiac tissue. The long-term vision of this research is to replace the current strategy of applying painful and sometimes tissue damaging electric shock – currently the only reliable way to terminate life-threatening fibrillation – by a more subtle but equally effective intervention. The book maps out a number of promising research directions for biophysicists and medical researchers working on the origins and treatment of cardiac arrhythmias.