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Record Nr. |
UNINA9910800117303321 |
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Autore |
Yau Stephen S. -T |
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Titolo |
Mathematical Principles in Bioinformatics / / by Stephen S.-T. Yau, Xin Zhao, Kun Tian, Hongyu Yu |
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Pubbl/distr/stampa |
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Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023 |
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ISBN |
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Edizione |
[1st ed. 2023.] |
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Descrizione fisica |
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1 online resource (177 pages) |
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Collana |
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Interdisciplinary Applied Mathematics, , 2196-9973 ; ; 58 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Bioinformatics |
Mathematics |
Applications of Mathematics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Preface -- 1 Biological Overview -- 2 Bioinformatics Databases -- 3 Sequence Alignment -- 4 The Time-Frequency Spectral Analysis and Applications in Bioinformatics -- 5 Graphical Representation of Sequences and Its Application -- 6 The Development and Applications of the Natural Vector Method -- 7 Convex Hull Principle and Distinguishing Proteins from Arbitrary Amino Acid Sequences -- 8 New Features or Metric on Sequence Comparison -- References. |
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Sommario/riassunto |
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This textbook introduces bioinformatics to students in mathematics with no biology background assumed and it provides solid mathematical tools for biology students along with an understanding of how to implement them in bioinformatics problems. In addition to the basics, the text offers new approaches to understanding biological sequences. The concise presentation distinguishes itself from others on the subject, discussing and providing principles that relate to current open problems in bioinformatics as well as considering a variety of models. The convex hull principle is highlighted, opening a new interdisciplinary research area at the intersection of biology, mathematics, and computer science. Prerequisites include first courses in linear algebra, probability and statistics, and mathematical analysis. |
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Researchers in mathematics, biology, and math-biology, will also find aspects of this text useful. This textbook is written based on the authors' research works that have beenpublished in various journals along with the lecture notes used when teaching bioinformatics courses at the University of Illinois at Chicago and at Tsinghua University. The content may be divided into two parts. The first part includes three chapters, introducing some basic concepts. Chapter 1 provides biological background in molecular biology for mathematicians. Chapter 2 describes biological databases that are commonly used. Chapter 3 is concerned with alignment methods including global/local alignment, heuristic alignment, and multiple alignment. The second part consisting of five chapters, describes several bioinformatics principles using a rigorous mathematical formulation. Chapter 4 introduces the time-frequency spectral principle and its applications in bioinformatics. In Chapters 5 and 6, two strategies are used, the graphical representation and the natural vector method, to represent biological sequences, and conduct sequence comparison and phylogenetic analysis without alignment. Chapter 7 presents the convex hull principle and shows how it can be used to mathematically determine whether a certain amino acid sequence can be a protein. The last chapter summarizes additional mathematical ideas relating to sequence comparisons, such as new feature vectors and metrics. This part focuses on the governing principle in biology and provides plenty of alignment-free methods, which cannot be found in any other book. |
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2. |
Record Nr. |
UNINA9910300347603321 |
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Autore |
Augustin Goran |
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Titolo |
Acute Abdomen During Pregnancy / / by Goran Augustin |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (584 p.) |
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Disciplina |
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Soggetti |
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Surgery |
Gynecology |
Midwifery |
Internal medicine |
Radiology |
General Surgery |
Internal Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Surgery: Acute appendicitis -- Acute biliary tract diseases -- Acute pancreatitis -- Non-traumatic gastroduodenal perforations -- Incarcerated abdominal wall hernias -- Symptomatic diaphragmatic hernia -- Intestinal obstruction -- Acute inflammatory bowel disease -- Splenic rupture -- Abdominal trauma -- Miscellaneous conditions.- Gynecology: General considerations -- Adnexal torsion -- (Isolated) torsion of fallopian tube -- Hemorrhagic functional ovarian cysts -- Pelvic inflammatory disease and tubo-ovarian abscess -- Ruptured ectopic pregnancy -- Torsion of the gravid uterus -- Spontaneous uterine rupture -- Degenerating uterine myomas -- Ruptured endometriotic cyst -- Gynecologic postpartum abdominal pain. |
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Sommario/riassunto |
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This book will help the reader to recognize, diagnose, and efficiently treat most of the acute abdominal disorders that may be encountered |
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in the pregnant patient, whether associated with or incidental to the pregnancy. A wide range of conditions are addressed, including some which are very rare as well as those more frequently seen, such as acute appendicitis and acute cholecystitis. The principles underlying diagnosis and therapy are clearly explained. Particular features in the clinical presentation of pregnant patients are highlighted, and specific diagnostic and therapeutic algorithms and protocols, described. Attention is drawn to the diagnostic difficulties that may arise from atypical presentations in these patients and to restrictions on the use of certain diagnostic imaging studies. The text is complemented by more than 200 figures relevant to clinical practice. Acute Abdomen During Pregnancy is designed to meet the needs of both the gynecologist and the general or abdominal surgeon, who together form the multidisciplinary team mandatory for effective treatment that will safeguard mother and baby. |
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