1.

Record Nr.

UNINA9910298615103321

Autore

Radiom Milad

Titolo

Correlation Force Spectroscopy for Single Molecule Measurements / / by Milad Radiom

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015

ISBN

3-319-14048-5

Edizione

[1st ed. 2015.]

Descrizione fisica

1 online resource (135 p.)

Collana

Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053

Disciplina

539.6

Soggetti

Spectrum analysis

Microscopy

Atomic structure

Molecular structure

Chemical engineering

Spectroscopy/Spectrometry

Spectroscopy and Microscopy

Atomic/Molecular Structure and Spectra

Industrial Chemistry/Chemical Engineering

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Dissertation submitted to the faculty of Virginia Polytechnic Institute and State University in fulfillment of the requirements for the degree of Doctor of Philosophy in Chemical Engineering, William A. Ducker, Chair, John Y. Walz Mark Paul Richey M. Davis May 7, 2014 Blacksburg, VA."

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

Introduction -- Correlation Force Spectroscopy -- Dynamics of Single Molecules -- Microrheology with Correlation Force Spectroscopy -- Development of Colloidal Probe Correlation Force Spectroscopy: Case Study -- Correlation Force Spectroscopy for Single Molecule Measurements -- Single Molecule Force Spectroscopy of Dextran -- Single Molecule Force Spectroscopy of Single-Stranded DNA -- Summary.

Sommario/riassunto

This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to µm3) at



kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers.  CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers. The book also discusses development of CFS, its advantages over AFM, and its application in single molecule force spectroscopy and micro-rheology.