| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910298584603321 |
|
|
Autore |
Ferraz de Paiva Raphael Enoque |
|
|
Titolo |
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins [[electronic resource] /] / by Raphael Enoque Ferraz de Paiva |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2018.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (184 pages) |
|
|
|
|
|
|
Collana |
|
Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053 |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Inorganic chemistry |
Organometallic chemistry |
Proteins |
Mass spectrometry |
Bioorganic chemistry |
Immunology |
Inorganic Chemistry |
Organometallic Chemistry |
Protein-Ligand Interactions |
Mass Spectrometry |
Bioorganic Chemistry |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di contenuto |
|
Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C,N and k2N,N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with |
|
|
|
|
|
|
|
|
|
|
ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling. |
|
|
|
|
|
| |