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1. |
Record Nr. |
UNINA9910298411603321 |
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Titolo |
Channelopathies in Heart Disease / / edited by Dierk Thomas, Carol Ann Remme |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
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ISBN |
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Edizione |
[1st ed. 2018.] |
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Descrizione fisica |
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1 online resource (435 pages) |
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Collana |
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Cardiac and Vascular Biology, , 2509-7830 ; ; 6 |
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Disciplina |
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Soggetti |
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Biomedical engineering |
Cardiology |
Regenerative medicine |
Tissue engineering |
Cardiovascular system |
Bioinformatics |
Biomedical Engineering/Biotechnology |
Regenerative Medicine/Tissue Engineering |
Cardiovascular Biology |
Computational Biology/Bioinformatics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- Part 1: (Dys)function of cardiac ion channels. Cardiac sodium channel (dys)function and inherited arrhythmia syndromes -- Potassium channels in the heart -- Voltage-gated calcium channels and their roles in cardiac electrophysiology -- HCN channels and cardiac pacemaking -- Dysregulation of ionic homeostasis: relevance for cardiac arrhythmias -- Part 2: Cardiac channelopathies: clinical and genetic findings. Long and short QT syndromes -- Brugada syndrome: current perspectives -- Sinus node disease and cardiac conduction disease -- Catecholaminergic polymorphic ventricular tachycardia -- Idiopathic ventricular fibrillation and early repolarization -- Atrial fibrillation -- Genetic testing for inheritable cardiac channelopathies -- Part 3: Research into cardiac channelopathies: new avenues. Novel imaging techniques in cardiac ion channel research -- Transgenic |
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animal models of cardiac channelopathies – benefits and limitations -- Induced pluripotent stem cell-derived cardiomyocytes: towards personalized therapeutic strategies?. . |
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Sommario/riassunto |
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This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines. . |
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2. |
Record Nr. |
UNINA9910483839503321 |
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Autore |
Cao Xi-Ren |
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Titolo |
Relative Optimization of Continuous-Time and Continuous-State Stochastic Systems / / by Xi-Ren Cao |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (376 pages) |
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Collana |
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Communications and Control Engineering, , 0178-5354 |
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Disciplina |
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Soggetti |
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Automatic control |
Calculus of variations |
Markov processes |
Control and Systems Theory |
Calculus of Variations and Optimal Control; Optimization |
Markov model |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Chapter 1. Introduction -- Chapter 2. Optimal Control of Markov Processes: Infinite Horizon -- Chapter 3. Optimal Control of Diffusion Processes -- Chapter 4. Degenerate Diffusion Processes -- Chapter 5. Multi-Dimensional Diffusion Processes -- Chapter 6. Performance-Derivative-Based Optimization -- Appendices -- Index. |
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Sommario/riassunto |
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This monograph applies the relative optimization approach to time nonhomogeneous continuous-time and continuous-state dynamic systems. The approach is intuitively clear and does not require deep knowledge of the mathematics of partial differential equations. The topics covered have the following distinguishing features: long-run average with no under-selectivity, non-smooth value functions with no viscosity solutions, diffusion processes with degenerate points, multi-class optimization with state classification, and optimization with no dynamic programming. The book begins with an introduction to relative optimization, including a comparison with the traditional approach of dynamic programming. The text then studies the Markov process, focusing on infinite-horizon optimization problems, and moves on to discuss optimal control of diffusion processes with semi-smooth value functions and degenerate points, and optimization of multi-dimensional diffusion processes. The book concludes with a brief overview of performance derivative-based optimization. Among the more important novel considerations presented are: the extension of the Hamilton–Jacobi–Bellman optimality condition from smooth to semi-smooth value functions by derivation of explicit optimality conditions at semi-smooth points and application of this result to degenerate and reflected processes; proof of semi-smoothness of the value function at degenerate points; attention to the under-selectivity issue for the long-run average and bias optimality; discussion of state classification for time nonhomogeneous continuous processes and multi-class optimization; and development of the multi-dimensional Tanaka formula for semi-smooth functions and application of this formula to stochastic control of multi-dimensional systems with degenerate points. The book will be of interest to researchers and students in the field of stochastic control and performance optimization alike. |
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