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1. |
Record Nr. |
UNINA9910298340503321 |
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Titolo |
Translation and Its Regulation in Cancer Biology and Medicine / / edited by Armen Parsyan |
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Pubbl/distr/stampa |
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Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (709 p.) |
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Disciplina |
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Soggetti |
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Cancer - Research |
Oncology |
Cytology |
Molecular biology |
Biochemistry |
Medicine |
Cancer Research |
Cell Biology |
Molecular Medicine |
Biochemistry, general |
Biomedicine, general |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Preface -- Introduction -- PART I. TRANSALATION MACHINERY IN CANCER -- Mechanism of Translation in Eukaryotes -- Diverse Mechanisms of Translation Regulation and Their Role in Cancer -- eIF4E and Its Binding Proteins -- RNA Helicases and Their Cofactors -- PDCD4 -- eIF4G -- eIF3 -- The eIF2 Complex and eIF2α -- eIF5A -- eIF6 -- Translation Elongation -- Ribosomes -- Current and Emerging Therapies Targeting Translation -- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER -- mTOR and |
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Regulation of Translation -- Ribosomal Protein S6 and S6 Kinases -- eIF4E Phosphorylation Downstream of MAPK Pathway -- PART III. CELL FATE AND TRANSLATION IN CANCER -- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells -- Translation and Apoptosis in Cancer -- Translation in Cancer at Hypoxia -- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES -- Melanoma and Non-Melanoma Skin Cancers -- Sarcomas -- Hematological Malignancies and Premalignant Conditions -- Brain Tumors -- Head and Neck Cancers -- Breast Cancer -- Cancers of the Respiratory System -- Gastric and Esophageal Cancers -- Colorectal Cancers -- Hepatic, Pancreatic and Biliary Cancers -- Pancreatic Neuroendocrine Tumors -- Gynecologic Cancers -- Prostate Cancer -- Cancers of the Urinary System -- List of Abbreviations. |
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Sommario/riassunto |
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This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine. . |
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2. |
Record Nr. |
UNINA9910484595303321 |
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Autore |
Karafili Elona |
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Titolo |
Cluster Dynamics in Transition Economies : The Case of Albania / / by Elona Karafili |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (xiii, 74 pages) : illustrations |
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Collana |
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SpringerBriefs in Geography, , 2211-4173 |
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Disciplina |
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Soggetti |
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Economic geography |
Urban economics |
Regional economics |
Spatial economics |
Geography |
Economic Geography |
Urban Economics |
Regional and Spatial Economics |
Regional Geography |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Chapter 1. Introduction -- Chapter 2. Economic Clusters And Regional Competitiveness -- Chapter 3. Cluster Policies -- Chapter 4. Cluster Dynamics In Albania -- Chapter 5. Dynamic Planning For Cluster Development. |
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Sommario/riassunto |
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This book analyses the effectiveness of policies adopted in cluster promotion, using complexity thinking and evolutionary economic geography approaches. It studies cluster dynamics in transition economies, exploring the case of Albania. In developing countries, the ‘model’ of the developed countries, is often seen as the endpoint of a trajectory that must be followed meticulously, implying a view on modernization as a linear and uniform process. They tend to import policies from these ‘success models’ showing minimal regard to their context and institutional capabilities; therefore, more often than not, such policies show little effectiveness. This research on cluster policies |
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in Albania confirms this. It suggests that in Albania there is a need to revise the way of thinking about clusters, considering them first and foremost as relational networks, instead of physically bound industrial districts. While there isquestioning of top-down policies and the national innovation systems prerogative, the suggested model by this research, in line with some of the most recent policy frameworks, advocates the need for flexibility, bottom-up initiatives and place-based approaches. By means of conclusion, the book comes up with an alternative model of territorial policies for cluster development, shifting from ‘static’ towards ‘dynamic’ planning. |
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