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Record Nr. |
UNINA9910298340403321 |
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Autore |
Pandey Amita |
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Titolo |
The UNC-53-mediated Interactome : Analysis of its Role in the Generation of the C. elegans Connectome / / by Amita Pandey, Girdhar K. Pandey |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (91 p.) |
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Collana |
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SpringerBriefs in Neuroscience, , 2191-558X ; ; 0 |
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Disciplina |
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Soggetti |
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Neurosciences |
Neurobiology |
Neurology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Introduction -- Guidance molecules required for growth cone migrations of cells and axons -- Mechanism for asymmetric localization of guidance receptors during growth cone migration and outgrowth -- Signaling pathways downstream of the guidance cues and receptors -- Functional characterization of adaptor protein UNC-53 during axon outgrowth and cell migration. |
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Sommario/riassunto |
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This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders. In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development . |
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