Friedrich Nietzsche : die fröhliche wissenschaft. / / herausgegeben von Christian Benne und Jutta Georg

• Record Nr.: UNINA9910797571403321
• Pubbl/distr/stampa: Berlin, [Germany] ; ; Boston, [Massachusetts] : , : De Gruyter, , 2015; ©2015
• ISBN: 3-11-044030-X; 3-11-043174-2
• Descrizione fisica: 1 online resource (196 p.)
• Collana: Klassiker Auslegen, , 2192-4554 ; ; Band 57
• Classificazione: CG 5915
• Disciplina: 193
• Soggetti: Religion - Philosophy; Philosophy
• Lingua di pubblicazione: Tedesco
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Frontmatter -- Inhalt -- Siglenverzeichnis -- Einführung -- „die letzte Entscheidung über den Text zwingt zum scrupulösesten ‚Hören‘ von Wort und Satz“ – Textgenese und Druckgeschichte der Fröhlichen Wissenschaft -- Vorrede: Die Bedeutung der Zurückdatierung -- Nicht mit der Hand allein: „‚Scherz, List und Rache‘. Vorspiel in deutschen Reimen“ -- „eine unaufhaltsam rollende Maschine im Kopfe“ -- Der „gute Wille zum Scheine“ -- Nietzsche Naturalizing -- Philosophie als Jasagen -- Fünftes Buch: „Wir Furchtlosen“ -- Stagnation und Höhenflug -- A Concluding Fable -- Auswahlbibliographie -- Personenregister -- Autorinnen und Autoren
• Sommario/riassunto: Die Fröhliche Wissenschaft gilt als das erste durchkomponierte Werk von Nietzsches reifer Philosophie. Sie formulierte erstmalig jene Motive, die man später zu seinen ‚Lehren‘ verkürzte, darunter den Tod Gottes, das amor fati, die Lebensbejahung, den Willen zur Macht, den Perspektivismus. Schon Giorgio Colli sprach von „Nietzsches gelungenstem Versuch philosophischer Mitteilung“. Mit ihrer Aufwertung begann auch die moderne Nietzscheforschung.; The Gay Science is regarded as the first fully developed presentation of Nietzsche’s mature philosophy. For the first time, it formulated the motifs later referred to as his “teachings,” including the death of God, ; the amor fati, the affirmation of life, the will to power, and perspectivism. G. Colli called it “Nietzsche’s most successful attempt at philosophical communication.” Its reception signaled the beginning of modern Nietzsche research.

Nicotinic Receptors / / edited by Robin A.J. Lester

• Record Nr.: UNINA9910298331503321
• Pubbl/distr/stampa: New York, NY : , : Springer New York : , : Imprint : Humana, , 2014
• ISBN: 1-4939-1167-8
• Edizione: [1st ed. 2014.]
• Descrizione fisica: 1 online resource (468 p.)
• Collana: The Receptors, , 1048-6909 ; ; 26
• Disciplina: 610; 612.8; 612.8042
• Soggetti: Neurosciences; Neurochemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: On the Discovery of the Nicotinic Acetylcholine Receptor Channel -- Molecular Structure and Gating -- Molecular Underpinnings of Neuronal Nicotinic Acetylcholine Receptor Expression -- Presynaptic Nicotinic Receptors: Subtypes and Function -- Functional Distribution and Regulation of Neuronal Nicotinic Acetylcholine Receptors in the Mammalian Brain -- Nicotinic Signaling in Development -- Presynaptic Nicotinic Acetylcholine Receptors & The Modulation Of Circuit Excitability -- Autonomic Nervous System Transmission -- Nicotinic Receptors in the Spinal Cord -- Slow Synaptic Transmission in the Central Nervous System -- The Effects of Nicotine on Learning and Memory -- Nicotinic Receptors as Targets for Novel Analgesics and Anti-Inflammatory Drugs -- Nicotinic Acetylcholine Receptors and the Roles of the Alpha7 Subunit -- Role of Central Serotonin Receptors in Nicotine Addiction -- Neuronal Nicotinic Acetylcholine Receptors in Reward and Addiction -- Genetic Contributions of the α5 Nicotinic ; Receptor Subunit to Smoking Behavior -- Smoking‐Related Genes and Functional Consequences -- Nicotinic Acetylcholine Receptors Along the Habenulo-Interpeduncular Pathway: Roles in Nicotine Withdrawal and Other Aversive Aspects -- Nicotinic Acetylcholine Receptors in Alzheimer’s and Parkinson’s Disease -- Nicotinic Receptors and Mental Illness -- Current & Future Trends in Drug Discovery and Development Related to Nicotinic Receptors.
• Sommario/riassunto: A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system, and discussion of their implications in learning and memory, addiction, and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression, and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.