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Record Nr. |
UNINA9910298315403321 |
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Autore |
Inuzuka Hiroyuki |
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Titolo |
SCF and APC E3 Ubiquitin Ligases in Tumorigenesis [[electronic resource] /] / by Hiroyuki Inuzuka, Wenyi Wei |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (119 p.) |
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Collana |
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SpringerBriefs in Cancer Research, , 2194-1173 |
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Disciplina |
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Soggetti |
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Cancer research |
Cell cycle |
Proteins |
Cancer Research |
Cell Cycle Analysis |
Protein Structure |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives. |
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Sommario/riassunto |
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This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent |
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