Nutrition, Exercise and Epigenetics: Ageing Interventions / / edited by Byung Pal Yu

• Record Nr.: UNINA9910298296703321
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
• ISBN: 9783319148304; 3-319-14829-X
• Edizione: [1st ed. 2015.]
• Descrizione fisica: 1 online resource (279 p.)
• Collana: Healthy Ageing and Longevity, , 2199-9015 ; ; 2
• Disciplina: 305.26; 571.6; 572.6; 610; 612.67; 616.2; 618.97
• Soggetti: Medicine - Research; Biology - Research; Geriatrics; Cytology; Nutrition; Aging; Post-translational modification; Biomedical Research; Cell Biology; Ageing; Post-translational Modifications
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Preface -- Epigenetics and Nutrition -- Calorie restriction as a potent epigenetic modifier -- Anti-inflammatory action of calorie restriction for aging intervention -- Hormonal influence and modulation on aging ; -- Epigenetic modification by exercise -- Physiological bases and underlying mechanisms of exercise -- Sarcopenia and its intervention -- Nutritional impacts on osteopenia and osteoporosis -- Nutritional interventions for cardiac aging and age-related cardiovascular diseases -- Nutritional influence on aging brain -- Mechanistic bases of calorie restriction mimetics -- Lessons learned from calorie restricted non-human primate research.
• Sommario/riassunto: This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing. .