1.

Record Nr.

UNINA9910298292303321

Titolo

Stem Cell Biology in Neoplasms of the Central Nervous System / / edited by Moneeb Ehtesham

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015

ISBN

3-319-16537-2

Edizione

[1st ed. 2015.]

Descrizione fisica

1 online resource (200 p.)

Collana

Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 853

Disciplina

571.6

610

612.8

614.5999

Soggetti

Cancer research

Stem cells

Neurosciences

Cancer Research

Stem Cells

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain -- The SVC and Its Relationship to Stem Cell Based Neuro-oncogenesis. - Isolation and characterization of stem cells for human central nervous system malignancies. - The role of stem cells in pediatric central nervous system malignancies. - Laboratory models for central nervous system tumor stem cell research. - Radiation Therapy for Glioma Stem Cells -- Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma -- Immunobiology and Immunotherapeutic targeting of glioma stem cells -- Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.

Sommario/riassunto

This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely



differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.   The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.