1.

Record Nr.

UNINA9910298268203321

Titolo

Inflammation and Lung Cancer / / edited by Steven M. Dubinett

Pubbl/distr/stampa

New York, NY : , : Springer New York : , : Imprint : Springer, , 2015

ISBN

1-4939-2724-8

Edizione

[1st ed. 2015.]

Descrizione fisica

1 online resource (215 p.)

Disciplina

610

614.5999

616.07

616.079

616.9041

Soggetti

Cancer - Research

Pathology

Medical microbiology

Immunology

Cancer Research

Medical Microbiology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references at the end of each chapters and index.

Nota di contenuto

Inflammation and Lung Cancer: The relationship to COPD -- Inflammation and Lung Cancer: The role of EMT -- Inflammation and Lung Cancer: Molecular pathology -- Inflammation and Lung Cancer: Prevention -- Inflammation and Lung Cancer: The Link to Angiogenesis -- Inflammation and Lung Cancer: Eicosanoids -- Inflammation and Lung Cancer: Addressing Inflammation with Immunotherapy.

Sommario/riassunto

This volumeĀ  presents aspects of the inflammatory tumor microenvironment (TME) and its many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs), and an increase in a stem cell phenotype. The volume also covers the mechanisms of inflammatory mediators. Chronic overexpression of inflammatory mediators in the TME, as seen in



smokers and patients with non-small cell lung cancer (NSCLC), can also lead to increased tumor initiation, progression, invasion, and metastasis. The volume will provide a comprehensive perspective of the latest findings and summaries of progress made regarding inflammation and its connection to lung cancer.