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Record Nr. |
UNINA9910298158303321 |
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Autore |
Berger Mitchel |
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Titolo |
Gliomas [[electronic resource] /] / volume editors, Mitchel S. Berger and Michael Weller |
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Pubbl/distr/stampa |
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Amsterdam : , : Elsevier, , [2016] |
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©2016 |
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ISBN |
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0-12-803007-0 |
0-12-802997-8 |
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Descrizione fisica |
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1 online resource (464 p.) |
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Collana |
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Handbook of clinical neurology ; ; 3rd series, volume 134 |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Front Cover; Gliomas; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Diagnosis and treatment; Chapter 1: Epidemiology; Descriptive epidemiology; Glioma incidence by age and histologic subtype; Differences in glioma incidence by sex, ethnicity, and geographic location; Incidence of molecular subgroups of glioma; Inherited risk factors for glioma; Hereditary cancer syndromes associated with glioma risk; Genome-wide association studies of glioma; Telomere maintenance and glioma; Telomere biology and heritability of telomere length: |
Telomere length and risk of gliomaTelomere lengthening and cancer; Environmental and developmental risk factors; Allergies, infections, and immunologic risk factors; Ionizing radiation; Nonionizing radiation; Other investigated but inconclusive factors; Patient survival following diagnosis; Associations with age, tumor subtype, and treatment; Prognostic markers; Conclusions; Gene abbreviations used; References; Chapter 2: Presenting Signs and Symptoms in Brain Tumors; Introduction; Generalized Symptoms And signs; Headache; Nausea and Vomiting; Altered Mental Status; Papilledema; Seizure |
Clinical Features of Increased Intracranial PressureCSF Obstruction; |
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Herniation Syndromes; Localizing Symptoms and Signs of Intracranial Neoplasms; Invasion From The skull; Frontal-lobe Tumors; General Features; Temporal-lobe Tumors; General Features; Seizures; Visual Deficits; Dysphasia; Cognitive and Memory Dysfunction; Parietal-lobe Tumors; Seizure; Sensory Abnormalities; Visual Disturbances; Dyspraxia; Dysphasia; Occipital Tumors; Diencephalic Tumors; Pineal-region Tumors; Mesencephalic Tumors; Pontine Tumors; Cerebellar Tumors; Cerebellopontine Angle Tumors; Medullary Tumors |
Spinal Cord TumorsReferences; Chapter 3: Neuroimaging; Introduction; Conventional MRI in Glioma; Astrocytic Tumors; Diffuse low-grade Astrocytoma; Anaplastic Astrocytoma; Glioblastoma; Oligodendroglial Tumors; Oligodendroglioma; Anaplastic Oligodendroglioma; Ependymal Tumors; Ependymoma; Subependymoma; Neuronal Tumors; Ganglioglioma; Dysembryoplastic Neuroepithelial tumor; Central Neurocytoma; Advanced MRI Techniques; Diffusion-weighted Imaging; Diffusion Tensor Imaging; Magnetic Resonance Spectroscopy; Functional Magnetic Resonance Imaging; MR Perfusion Imaging |
Dynamic contrast-enhanced Imaging TechniquesDynamic Susceptibility contrast-enhanced Mri (Dsce-MRI); Dynamic contrast-enhanced MRI; Dynamic contrast-enhanced CT; Arterial Spin Labeling; Clinical Applications of MRI; Distinguishing Glioma From Other Lesions; Distinguishing Glioma From a Solitary Metastasis; Distinguishing Glioma From Cerebral Abscess; Distinguishing Glioma From Inflammatory Lesions; Distinguishing Glioma From Lymphoma; Grading Glioma and Identifying Histologic Subtypes; Identifying Malignant Transformation In LGG; Treatment Planning; Surgical Guidance; Radiotherapy Guidance |
Measuring and Predicting Therapeutic Response |
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2. |
Record Nr. |
UNINA9910782552403321 |
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Titolo |
Developing solid oral dosage forms : pharmaceutical theory and practice / / executive editors, Yihong Qiu, Yisheng Chen, Geoff G.Z. Zhang ; associate editors, Linong Liu, William R. Porter |
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Pubbl/distr/stampa |
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Amsterdam ; ; Boston ; ; London, : Academic, 2009 |
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ISBN |
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1-282-73750-3 |
9786612737503 |
0-08-093272-X |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (976 pages) |
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Altri autori (Persone) |
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QiuYihong |
ChenYisheng (Of Novast Laboratories) |
ZhangGeoff G. Z |
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Disciplina |
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Soggetti |
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Solid dosage forms |
Solid dosage forms - Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice; Copyright Page; Contents; List of Contributors; Foreword; PART I: THEORIES AND TECHNIQUES IN THE CHARACTERIZATION OF DRUG SUBSTANCES AND EXCIPIENTS; Chapter 1. Solubility of Pharmaceutical Solids; 1.1 Introduction; 1.1.1 Implication of Solubility in Dosage Form Development; 1.1.2 Basic Concepts of Solubility and Dissolution; 1.2 Thermodynamics of Solutions; 1.2.1 Volume of Mixing; 1.2.2 Enthalpy of Mixing; 1.2.3 Entropy of Mixing; 1.2.4 Free Energy of Mixing; 1.3 Theoretical Estimation of Solubility |
1.3.1 Ideal Solutions; 1.3.2 Effect of Crystallinity; 1.3.3 Non-ideal Solutions; 1.3.4 Regular Solution Theory; 1.3.5 Aqueous Solution Theory; 1.3.6 The General Solubility Equation (GSE); 1.4 Solubilization of Drug Candidates; 1.4.1 Solubility Enhancement by pH Control and Salt Formation; 1.4.2 Solubilization Using Complexation; 1.4.3 Solubilization by Cosolvents; 1.4.4 Solubilization by Surfactants (Micellar Solubilization); 1.4.5 Solubilization by Combination of |
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Approaches; 1.5 Experimental Determination of Solubility; 1.5.1 Stability of Solute and Solvent; 1.5.2 Shakers and Containers |
1.5.3 Presence of Excess Undissolved Solute; 1.5.4 Determination of Equilibrium; 1.5.5 Phase-separation; 1.5.6 Determination of Solute Content in the Dissolved Phase; 1.5.7 Experimental Conditions; Chapter 2. Crystalline and Amorphous Solids; 2.1 Introduction; 2.2 Definitions and Categorization of Solids; 2.3 Thermodynamics and Phase Diagrams; 2.3.1 Polymorphs; 2.3.2 Solvates/Hydrates; 2.3.3 Cocrystals; 2.3.4 Amorphous Solids; 2.4 Pharmaceutical Relevance and Implications; 2.4.1 Solubility; 2.4.2 Dissolution Rate and Bioavailability; 2.4.3 Hygroscopicity; 2.4.4 Reactivity and Chemical Stability |
2.4.5 Mechanical Properties; 2.5 Transformations Among Solids; 2.5.1 Induced by Heat; 2.5.2 Induced by Vapor; 2.5.3 Induced by Solvents; 2.5.4 Induced by Mechanical Stresses; 2.6 Methods of Generating the Solids; 2.6.1 Through Gas; 2.6.2 Through Liquid; 2.6.3 Through Solid; 2.7 Amorphous Drugs and Solid Dispersions; 2.7.1 Characteristics of Amorphous Phases; 2.7.2 Characteristics of Amorphous Solid Dispersions; 2.7.3 Crystallization of Amorphous Drug and Dispersions; 2.8 Special Topics; 2.8.1 Polymorph Screening and Stable Form Screening; 2.8.2 High Throughput Crystallization |
2.8.3 Miniaturization in Crystallization; Chapter 3. Analytical Techniques in Solid-state Characterization; 3.1 Introduction; 3.2 Review of Analytical Techniques and Methods; 3.3 Microscopic Methods; 3.3.1 Optical Microscopy; 3.3.2 Electron Microscopy; 3.4 Thermal Analysis; 3.4.1 Differential Scanning Calorimetry; 3.4.2 Thermogravimetric Analysis; 3.4.3 Microcalorimetry; 3.5 Diffraction Methods; 3.5.1 Single-crystal X-ray Diffraction; 3.5.2 Powder X-ray Diffraction; 3.6 Vibrational Spectroscopy; 3.6.1 Infrared Spectroscopy; 3.6.2 Raman Spectroscopy; 3.6.3 Near-infrared ; 3.7 Solid-State Nuclear Magnetic Resonance Spectroscopy |
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Sommario/riassunto |
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This book is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. |
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