Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation

• Record Nr.: UNINA9910346756603321
• Autore: Florence E. Roufosse
• Pubbl/distr/stampa: Frontiers Media SA, 2018
• Descrizione fisica: 1 online resource (279 p.)
• Collana: Frontiers Research Topics
• Soggetti: Medicine
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of ; eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.

Argumentos cuantitativos y cualitativos en sociolingüística : segundo Coloquio de Cambio y Variación Lingüística / / edición a cargo de Pedro Martín Butragueño y Leonor Orozco

• Record Nr.: UNINA9910295759603321
• Autore: Orozco Leonor
• Pubbl/distr/stampa: El Colegio de México, 2014; Mexico, D.F. : , : El Colegio de Mexico, , 2014; ©2014
• ISBN: 607-564-040-1; 607-462-683-9
• Edizione: [Primera edición.]
• Descrizione fisica: 1 online resource (802 pages) : illustrations, maps
• Collana: Estudios de lingüística ; ; 21
• Soggetti: Sociolinguistics; Spanish language - Dialects - Mexico; Spanish language - Variation; Electronic books.
• Lingua di pubblicazione: Spagnolo
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Papers generated by the Segundo Coloquio de Cambio y Variación Lingüística, El Colegio de Mexico, October 5-7, 2010); "Cátedra Jaime Torres Bodet, Centro de Estudios Lingüísticos y Literarios, Laboratorio de Estudios Fónicos"--Page facing title page.
• Nota di bibliografia: Includes bibliographical references.
• Sommario/riassunto: Este volumen se ha dividido en cuatro secciones. "Variación fónica", "Contacto de variedades", "Morfosintaxis variable" y "Discurso y método sociolingüístico", se trabaja el español mexicano y el de otras variedades americanas, así como diferentes lenguas indoamericanas y la lengua de señas mexicana. Una última sección incluye la transcripción de la mesa redonda que tuvo lugar al final del coloquio. En esta discusión emergen dos métodos diferentes, uno que detecta tendencias cuantitativas en los datos y que busca después localizar las razones cualitativas de esa distribución, y otro que parte precisamente de las diferencias cualitativas en los materiales y que se preguntan después por las tendencias cuantitativas localizables.