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1. |
Record Nr. |
UNINA9910460672103321 |
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Titolo |
Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others] |
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Pubbl/distr/stampa |
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London, England : , : Academic Press, , 2015 |
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©2015 |
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ISBN |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (280 p.) |
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Disciplina |
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Soggetti |
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Cancer - Research |
Drug resistance in cancer cells |
Cancer - Chemotherapy |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability |
2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates |
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3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins |
3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References |
Chapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein |
5.2. BCRP |
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Sommario/riassunto |
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<i> ABC Transporters and Cancer</i> provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike. <br><br><ul><li>Provides information on cancer research</li><li>Outstanding and original reviews</li><li>Suitable for researchers and students</li></ul> |
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2. |
Record Nr. |
UNINA9910261118703321 |
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Autore |
Peter Matthias |
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Titolo |
John Maynard Keynes und die britische Deutschlandpolitik : Machtanspruch und ökonomische Realität im Zeitalter der Weltkriege 1919-1946 / / Matthias Peter |
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Pubbl/distr/stampa |
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De Gruyter, 1997 |
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Berlin ; ; Boston : , : Oldenbourg Wissenschaftsverlag, , [2009] |
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©1997 |
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ISBN |
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Edizione |
[Reprint 2015] |
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Descrizione fisica |
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1 online resource (339 p.) |
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Collana |
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Studien zur Zeitgeschichte ; ; 51 |
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Classificazione |
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Disciplina |
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Soggetti |
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Keynesian economics - History - 20th century |
World War, 1914-1918 - Economic aspects - Germany |
World War, 1939-1945 - Economic aspects - Germany |
Great Britain Foreign economic relations Germany |
Germany Foreign economic relations Great Britain |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (pages [327]-340) and index. |
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Nota di contenuto |
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Frontmatter -- Inhalt -- Vorwort -- Einleitung -- I. John Maynard Keynes' "The Economic Consequences of the Peace" und das lange Ende der Pax Britannica Oeconomica -- II. Der Gegensatz von wirtschaftlichem Wiederaufbau und Sicherheit vor Deutschland in der britischen Diskussion bis zur Kriegswende 1941 -- III. Das Malkin-Komitee und Keynes' Konzept eines deutschen Friedensbeitrages -- IV. Industrielle Abrüstung und Reparationen als Faktoren der Sicherheitspolitik: Die Formulierung des ersten "First Charge"-Prinzips -- V. Die Sowjetunion und das Problem der Sicherheit: Die Planungen im "Post-Hostilities Planning Staff" und im Foreign Office -- VI. Vom Krieg zum Frieden: Wirtschafts- und Sicherheitsprobleme der britischen Außenpolitik nach 1945 -- VII. Reparationen, Demontagen und Industrieniveauplan 1945/46: "First Charge"-Prinzip und "Economic Security" - Tragfähige Konzepte für die britische Deutschlandpolitik? -- Zusammenfassende Überlegungen: Die britische Deutschlandpolitik |
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zwischen Machtanspruch und Modernisierungszwang -- Abkürzungen -- Quellen und Literatur -- Personenverzeichnis |
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Sommario/riassunto |
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Das wissenschaftliche Werk und die politische Beratertätigkeit des Nationalökonomen John Maynard Keynes belegen die Bedeutung des Zusammenwirkens ökonomischer und politischer Faktoren für die britische Außenpolitik. Die Auseinandersetzung mit der deutschen Frage zieht sich dabei wie ein roter Faden durch Keynes ́ Schaffen. Bereits in seiner Kritik an der Versailler Friedensordnung hob er den Stellenwert einer integrativen Deutschlandpolitik für den europäischen Wiederaufbau hervor. Das Bemühen um die Realisierung der angesichts von New Deal und nationalsozialistischem Autarkiestreben entwickelt |
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