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Record Nr. |
UNINA9910462903903321 |
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Titolo |
Connexin cell communication channels : roles in the immune system and immunopathology / / edited by Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans |
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Pubbl/distr/stampa |
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Boca Raton : , : Taylor & Francis/CRC Press, , 2013 |
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ISBN |
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0-429-16585-4 |
1-4398-6258-3 |
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Descrizione fisica |
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1 online resource (363 p.) |
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Altri autori (Persone) |
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Oviedo-OrtaErnesto |
KwakBrenda R |
EvansW. Howard |
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Disciplina |
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Soggetti |
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Gap junctions (Cell biology) |
Connexins |
Inflammation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Front Cover; Contents; Preface; Editors; Contributors; Prequel: Gap Junctions, Hemichannels, and Cell-to-Cell Signalling; Chapter 1 - Communication in the Immune System by Connexin Channels; Chapter 2 - Gap Junctions and Connexins in the Hematopoietic-Immune System: Structural Considerations; Chapter 3 - Approaches for Studying the Role(s) of Gap Junctions in the Immune System; Chapter 4 - Gap Junctions in Antigen-Presenting Cells; Chapter 5 - Connect the Immune System: Roles of Gap Junctions in Antigen Presentation and T Cell Activation |
Chapter 6 - Gap Junctions and Connexins in the Immune Defense Against TumorsChapter 7 - Connexins in Atherosclerosis; Chapter 8 - Connexins in Lung Function and Inflammation; Chapter 9 - Effect of Oxidative Stress on Connexins in the Vasculature; Chapter 10 - Regulation of Gap Junctions and Cellular Coupling within the Microvasculature in Response to Acute Inflammation; Chapter 11 - Impact of Microglial Activation on Astroglial Connexin Expression and |
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Function in Brain Inflammation; Chapter 12 - A Role for Connexins in Inflammatory Disorders of the Epidermis |
Chapter 13 - Translating Basic Research on Cx43 Gap Junctions into Therapies for Reducing Scarring and Cardiac ArrhythmiaChapter 14 - Connexin-Based Therapeutic Approaches to Inflammation in the Central Nervous System; Chapter 15 - Enhancing Epithelial Tissue Repair and Reducing Inflammation by Targeting Connexins; Back Cover |
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Sommario/riassunto |
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Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in |
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2. |
Record Nr. |
UNINA9910255053803321 |
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Autore |
Sandoval-Almazán Rodrigo |
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Titolo |
Building Digital Government Strategies : Principles and Practices / / by Rodrigo Sandoval-Almazán, Luis F. Luna-Reyes, Dolores E. Luna-Reyes, J. Ramon Gil-Garcia, Gabriel Puron-Cid, Sergio Picazo-Vela |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
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ISBN |
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Edizione |
[1st ed. 2017.] |
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Descrizione fisica |
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1 online resource (123 pages) |
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Collana |
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Public Administration and Information Technology, , 2512-1812 ; ; 16 |
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Disciplina |
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Soggetti |
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Public administration |
Communication in politics |
Public policy |
Public Administration |
Political Communication |
Public Policy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Developing a Digital Government Strategy for Creating Public Value -- Conceptualizing and planning a Digital Government Project -- Financing Digital Government Innovation -- Building Collaboration Networks -- Managing Digital Government projects -- Opening Government: Open Data and Projects -- Fostering Citizen Engagement. |
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Sommario/riassunto |
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This book provides key strategic principles and best practices to guide the design and implementation of digital government strategies. It provides a series of recommendations and findings to think about IT applications in government as a platform for information, services and collaboration, and strategies to avoid identified pitfalls. Digital government research suggests that information technologies have the potential to generate immense public value and transform the relationships between governments, citizens, businesses and other stakeholders. However, developing innovative and high impact solutions for citizens hinges on the development of strategic institutional, organizational and technical capabilities. Thus far, particular characteristics and problems of the public sector organization promote the development of poorly integrated and difficult to maintain applications. For example, governments maintain separate applications for open data, transparency, and public services, leading to duplication of efforts and a waste of resources. The costs associated with maintaining such sets of poorly integrated systems may limit the use of resources to future projects and innovation. This book provides best practices and recommendations based on extensive research in both Mexico and the United States on how governments can develop a digital government strategy for creating public value, how to finance digital innovation in the public sector, how to building successful collaboration networks and foster citizen engagement, and how to correctly implement open government projects and open data. It will be of interest to researchers, practitioners, students, and public sector IT professionals that work in the design and implementation of technology-based projects and programs. |
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