|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910254481203321 |
|
|
Titolo |
Liquid Biopsies in Solid Tumors / / edited by Massimo Cristofanilli |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Cham : , : Springer International Publishing : , : Imprint : Humana, , 2017 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2017.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (X, 161 p. 14 illus., 12 illus. in color.) |
|
|
|
|
|
|
Collana |
|
Cancer Drug Discovery and Development, , 2196-9906 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Cancer research |
Cancer Research |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references at the end of each chapters and index. |
|
|
|
|
|
|
|
|
Nota di contenuto |
|
1.Blood-based diagnostics in solid tumors: an overview -- 2.Circulating tumor cells (CTCs) in primary disease: the seed for metastasis -- 3.Enumeration and molecular analysis of CTCs in metastatic disease: The breast cancer model -- 4.Epithelial-Mesenchymal Transition (EMT) and cancer stem cells (CSCs): The traveling metastasis -- 5.Detection and monitoring of circulating immune cells in solid tumors: shifting priorities -- 6.Circulating-free tumor DNA (ctDNA): the real-time liquid biopsy -- 7.CTCs and ctDNA: two tales of a complex biology -- 8.Exosome: decoding the messaging system. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) |
|
|
|
|