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1. |
Record Nr. |
UNINA9910466680903321 |
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Autore |
Montgomery Lucy Maud |
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Titolo |
Anne of Avonlea / / by Lucy Maud Montgomery |
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Pubbl/distr/stampa |
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Minneapolis, MN : , : First Avenue Editions, A division of Lerner Publishing Group, Inc., , [2016] |
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©2016 |
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ISBN |
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Descrizione fisica |
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Collana |
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Disciplina |
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Soggetti |
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Orphans |
Teachers |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910254481203321 |
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Titolo |
Liquid Biopsies in Solid Tumors / / edited by Massimo Cristofanilli |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Humana, , 2017 |
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ISBN |
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Edizione |
[1st ed. 2017.] |
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Descrizione fisica |
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1 online resource (X, 161 p. 14 illus., 12 illus. in color.) |
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Collana |
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Cancer Drug Discovery and Development, , 2196-9906 |
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Disciplina |
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Soggetti |
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Cancer - Research |
Cancer Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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1.Blood-based diagnostics in solid tumors: an overview -- 2.Circulating tumor cells (CTCs) in primary disease: the seed for metastasis -- 3.Enumeration and molecular analysis of CTCs in metastatic disease: The breast cancer model -- 4.Epithelial-Mesenchymal Transition (EMT) and cancer stem cells (CSCs): The traveling metastasis -- 5.Detection and monitoring of circulating immune cells in solid tumors: shifting priorities -- 6.Circulating-free tumor DNA (ctDNA): the real-time liquid biopsy -- 7.CTCs and ctDNA: two tales of a complex biology -- 8.Exosome: decoding the messaging system. |
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Sommario/riassunto |
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This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) |
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opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity. |
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