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Record Nr. |
UNINA9910254477003321 |
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Titolo |
Moyamoya Disease Explored Through RNF213 : Genetics, Molecular Pathology, and Clinical Sciences / / edited by Akio Koizumi, Kazuhiro Nagata, Kiyohiro Houkin, Teiji Tominaga, Susumu Miyamoto, Shigeo Kure, Elizabeth Tournier-Lasserve |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2017 |
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Edizione |
[1st ed. 2017.] |
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Descrizione fisica |
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1 online resource (VIII, 185 p. 36 illus., 22 illus. in color.) |
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Collana |
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Current Topics in Environmental Health and Preventive Medicine, , 2364-8341 |
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Disciplina |
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Soggetti |
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Neurology |
Nervous system - Surgery |
Public health |
Neurosurgery |
Public Health |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Part I: Prologue -- 1. A prologue to moyamoya disease and RNF213 -- 2. Concept of moyamoya Disease -- Part II: Genetic Epidemiology -- 3. Molecular Epidemiology in East Asian Countries and in the World -- Part III: Biochemistry, Function and Molecular Pathology -- 4. Molecular Biology of Mysterin/RNF213 -- 5. Physiological Role of Mysterin/RNF213 in Zebrafish -- 6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction -- 7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice -- 8. RNF213 and Circulating Factors in Patients with Moyamoya Disease -- 9. Genetics of Moyamoya beyond RNF213. Monogenic Moyamoya Syndromes -- Part IV: Clinical Management 10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management -- 11. Significance of RNF213 in Clinical Management in Japan -- 12. Significance of RNF213 in Clinical Management in China -- 13. The Different Forms of Moyamoya Disease and Their Clinical Management -- 14. Vascular Diseases Attributable to RNF213 Other than Moyamoya |
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Disease -- Part V: Epilogue -- Future Clinical Perspectives on RNF213 in Moyamoya Disease. |
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Sommario/riassunto |
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This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease. Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke. |
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