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Record Nr. |
UNINA9910254264303321 |
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Titolo |
Sperm Acrosome Biogenesis and Function During Fertilization / / edited by Mariano G. Buffone |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (176 p.) |
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Collana |
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Advances in Anatomy, Embryology and Cell Biology, , 2192-7065 ; ; 220 |
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Disciplina |
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Soggetti |
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Human physiology |
Medicine - Research |
Biology - Research |
Reproductive health |
Urology |
Human Physiology |
Biomedical Research |
Reproductive Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Preface -- The acrosome reaction: a historical perspective -- The acrosomal matrix -- Role of ion channels in the sperm acrosome reaction -- The molecules of sperm exocytosis -- Sperm capacitation and acrosome reaction in mammalian sperm -- Lipid regulation of acrosome exocytosis -- Role of actin cytoskeleton during mammalian sperm acrosomal exocytosis -- Site of mammalian sperm acrosome reaction. |
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Sommario/riassunto |
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Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of |
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unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process. . |
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