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1. |
Record Nr. |
UNINA9910337949603321 |
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Titolo |
Cholesterol Modulation of Protein Function : Sterol Specificity and Indirect Mechanisms / / edited by Avia Rosenhouse-Dantsker, Anna N. Bukiya |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (200 pages) |
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Collana |
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Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 1115 |
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Disciplina |
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Soggetti |
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Proteomics |
Proteins |
Cell membranes |
Molecular biology |
Protein Science |
Membrane Biology |
Molecular Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Part 1. Sterol specificity in modulating protein function: 1. Chirality effect on cholesterol modulation of protein function -- 2. A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs -- 3. Regulation of BK channel activity by cholesterol and its derivatives -- 4. Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying potassium channels -- Part 2. Indirect modulation of protein function by cholesterol: 5. Cholesterol effect on the physical properties of lipid membranes -- 6. Effect of cholesterol on the dipole potential of lipid membranes -- 7. Mass spectroscopy imaging of cholesterol -- 8. Cholesterol-dependent gating effects on ion channels. |
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Sommario/riassunto |
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In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The |
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application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems. |
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2. |
Record Nr. |
UNINA9910254210903321 |
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Titolo |
Recent results on nonlinear delay control systems : in honor of Miroslav Krstic / / edited by Iasson Karafyllis, Michael Malisoff, Frederic Mazenc, Pepe Pierdomenico |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (406 p.) |
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Collana |
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Advances in Delays and Dynamics, , 2197-117X ; ; 4 |
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Disciplina |
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Soggetti |
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Automatic control |
Artificial intelligence |
System theory |
Control and Systems Theory |
Artificial Intelligence |
Systems Theory, Control |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Stabilization of Nonlinear Delay Systems: A Tutorial on Recent Results -- Robust Stabilization of Nonlinear Globally Lipschitz Delay Systems -- Back stepping Designs in the Presence of Non-constant Delays on the Virtual Input -- Prediction-Based Control of Linear Systems by Compensating Input-Dependent Input Delay of Integral-Type -- State Estimation and Control of Nonlinear Systems with Large and Variable Measurement Delays -- On the Existence of the Normal Form for Nonlinear Delay Systems -- Compensating for Fatigue-Induced Time-Varying Delayed Muscle Response in Neuromuscular Electrical Stimulation Control -- Global and Local Weighted Homogeneity for Time-Delay Systems -- Sliding Mode Observer for Robust Fault Reconstruction of Time Delay Systems -- A Lyapunov-Krasovskii Methodology for a Class of Large-Scale Neutral Systems in an iISS Framework -- Input-to-State Stability of Switched Systems with Time Delays -- A Note on Converse Lyapunov Theorems for Neutral Systems -- Hybrid Dynamical Systems with Finite Memory -- Control-Oriented Modeling of Fluid Networks: A Time-Delay Approach -- Finite Spectrum Assignment for Nonlinear Time-delay Systems -- Improved Stability Criteria for Sampled-Data Systems with Input Saturations -- Inversion of State-Dependent Delay -- Sliding Mode Observer Based-Controller Design for Nonlinear Systems with Time Varying Delay -- An LMI Approach to Control of Exponentially Unstable Systems Subject to Saturation and Time-Varying Delay in the Input -- Identifiability and Observability of Nonlinear Time-Delay Systems with Unknown Inputs. |
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Sommario/riassunto |
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This volume collects recent advances in nonlinear delay systems, with an emphasis on constructive generalized Lyapunov and predictive approaches that certify stability properties. The book is written by experts in the field and includes two chapters by Miroslav Krstic, to whom this volume is dedicated. This volume is suitable for all researchers in mathematics and engineering who deal with nonlinear delay control problems and students who would like to understand the current state of the art in the control of nonlinear delay systems. |
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