1.

Record Nr.

UNINA9910254051003321

Autore

Kinoshita Masahiro

Titolo

Mechanism of Functional Expression of the Molecular Machines / / by Masahiro Kinoshita

Pubbl/distr/stampa

Singapore : , : Springer Singapore : , : Imprint : Springer, , 2016

ISBN

981-10-1486-8

Edizione

[1st ed. 2016.]

Descrizione fisica

1 online resource (X, 70 p. 30 illus., 24 illus. in color.)

Collana

SpringerBriefs in Molecular Science, , 2191-5407

Disciplina

539.6

Soggetti

Physical chemistry

Biophysics

Biological physics

Proteins 

Statistical physics

Dynamical systems

Physical Chemistry

Biological and Medical Physics, Biophysics

Protein-Ligand Interactions

Complex Systems

Statistical Physics and Dynamical Systems

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di bibliografia

Includes bibliographical references at the end of each chapters.

Nota di contenuto

Introduction -- Importance of Translational, Configurational Entropy of Water -- Molecular Machines -- Concluding Remarks: Mechanism of Functional Expression Common in the Molecular Machines.

Sommario/riassunto

This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified



manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.