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1. |
Record Nr. |
UNINA9910461033003321 |
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Titolo |
Urban futures for central Canada : perspectives on forecasting urban growth and form / / edited by Larry S. Bourne [and three others] |
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Pubbl/distr/stampa |
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Toronto, [Ontario] : , : Buffalo, [New York] : , : University of Toronto Press, , 1974 |
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©1974 |
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ISBN |
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Descrizione fisica |
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1 online resource (377 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Urbanization - Canada |
Cities and towns - Growth |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Studies in this volume directed by Centre for Urban and Community Studies University of Toronto"--Page before title page. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Frontmatter -- Contents -- Acknowledgments -- Introduction -- I. Forecasts of urban growth -- II. Growth and the urban system -- III. Growth and urban form -- APPENDIX A. Population forecasts for townships in Ontario, 1971-2001 -- APPENDIX B. Population forecasts for cities in Central Canada, 1971-2001 |
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Sommario/riassunto |
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Urban problems are now a dominant social issue: the essays in this volume consider the direction some of these problems may take in Central Canada. Three broad themes are discussed: forecasting (a spectrum of methodologies and urban forecasts); assessing the consequences of these forecasts at two levels (the growth of cities as an urban system and the growth and form of individual cities or urban regions); and assessing the role of changes in public policy. Specific topics include forecasting methodology in a spatial context, population and employment growth, migration, transportation, innovations, communication linkages, regional economic structure, economic fluctuations, the effects of public policy controls within a system of cities, land use and redevelopment, household mobility and social change, the spread of urban fields, and communities and neighbourhoods within cities. |
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2. |
Record Nr. |
UNINA9910254023703321 |
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Autore |
Zou Taotao |
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Titolo |
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) : Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents / / by Taotao Zou |
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Pubbl/distr/stampa |
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (175 p.) |
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Collana |
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Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053 |
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Disciplina |
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Soggetti |
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Chemistry, Inorganic |
Pharmaceutical chemistry |
Molecular biology |
Cancer - Research |
Inorganic Chemistry |
Medicinal Chemistry |
Molecular Medicine |
Cancer Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Introduction -- Experimental Section -- Gold(III) Complexes Containing N-Heterocyclic Carbene Ligand Serve as Dual Fluorescent Thiol “Switch-on” Probe and Anti-Cancer Agent -- A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Effectively Inhibits Tumor Growth and Angiogenesis in Vivo -- Luminescent Organoplatinum(II) Complexes Containing Bis(N-Heterocyclic Carbene) Ligands Selectively Target Endoplasmic Reticulum and Induce Potent Phototoxicity -- Summary and Evaluation. |
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Sommario/riassunto |
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This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands |
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which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment. |
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